Rapamycin-insensitive companion of mTOR (RICTOR) is a 1708-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6R327.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 65.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 33% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 36% |
What pLDDT means and how to read it
Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex,…
Component of the mechanistic target of rapamycin complex 2 (mTORC2), consisting in two heterotretramers composed of MTOR, MLST8, RICTOR and MAPKAP1/SIN1 (PubMed:15268862, PubMed:15467718, PubMed:17461779, PubMed:17599906, PubMed:29424687, PubMed:29567957, PubMed:33158864, PubMed:34519268, PubMed:35926713). The mTORC2 core complex associates with PRR5/PROTOR1 and/or PRR5L/PROTOR2…
Cell membrane, Endoplasmic reticulum membrane, Lysosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9T94 | EM | 2.6 Å | E=1-1708 |
| 9ZBK | EM | 2.6 Å | C=25-1694 |
| 9T93 | EM | 2.86 Å | E=1-1708 |
| 6ZWO | EM | 3.0 Å | F=1-1708 |
| 9T7J | EM | 3.0 Å | E/F=1-1708 |
| 9TDT | EM | 3.0 Å | E=1-1708 |
| 9T92 | EM | 3.1 Å | E/F=1-1708 |
| 6ZWM | EM | 3.2 Å | E/F=1-1708 |
| 7PE8 | EM | 3.2 Å | E=1-1708 |
| 9ZBJ | EM | 3.2 Å | C=23-1694 |
| 7TZO | EM | 3.28 Å | E/F=1-1708 |
| 9TDS | EM | 3.3 Å | E/F=1-1708 |
| 7PE7 | EM | 3.41 Å | E/F=1-1708 |
| 7PE9 | EM | 3.7 Å | E=1-1708 |
| 5ZCS | EM | 4.9 Å | E/F=1-1018 |
| 9TPW | EM | 6.4 Å | E/F=1-1708 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.