9T7J: Serine/threonine-protein kinase mTOR
cryo-EM structure of AKT phosphorylated mTOR complex 2, overall refinement. Determined by electron microscopy at 3.0 Å resolution. Released 22 Apr 2026.
- Method
- Electron microscopy
- Resolution
- 3.0 Å
- Organism
- Homo sapiens
- Chains
- 8
- Atoms
- 52,802
- Mol. weight
- 1171.72 kDa
- Ligands
- ADP, ZN, ATP, IHP
- Released
- 22 Apr 2026
Explore 9T7J in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9T7J contains 416 α-helices and 96 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 118 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 600-609 | 10 | |
| α-helix | 610-612 | 3 | |
| α-helix | 616-629 | 14 | |
| α-helix | 650-665 | 16 | |
| α-helix | 669-678 | 10 | |
| α-helix | 681-683 | 3 | |
| α-helix | 684-687 | 4 | |
| α-helix | 690-699 | 10 | |
| α-helix | 705-718 | 14 | |
| α-helix | 723-743 | 21 | |
| α-helix | 747-763 | 17 | |
| α-helix | 765-768 | 4 | |
| α-helix | 769-771 | 3 | |
| α-helix | 772-783 | 12 | |
| α-helix | 792-808 | 17 | |
| α-helix | 811-816 | 6 | |
| α-helix | 817-824 | 8 | |
| α-helix | 837-851 | 15 | |
| α-helix | 857-860 | 4 | |
| α-helix | 864-874 | 11 | |
| α-helix | 878-891 | 14 | |
| α-helix | 896-901 | 6 | |
| α-helix | 931-936 | 6 | |
| α-helix | 943-959 | 17 | |
| α-helix | 962-967 | 6 | |
| α-helix | 968-982 | 15 | |
| α-helix | 983-989 | 7 | |
| α-helix | 990-1003 | 14 | |
| α-helix | 1009-1023 | 15 | |
| α-helix | 1024-1030 | 7 | |
| α-helix | 1031-1041 | 11 | |
| α-helix | 1049-1063 | 15 | |
| α-helix | 1064-1069 | 6 | |
| α-helix | 1071-1084 | 14 | |
| α-helix | 1088-1090 | 3 | |
| α-helix | 1091-1100 | 10 | |
| α-helix | 1104-1107 | 4 | |
| α-helix | 1111-1122 | 12 | |
| α-helix | 1129-1142 | 14 | |
| α-helix | 1149-1151 | 3 | |
| α-helix | 1152-1165 | 14 | |
| α-helix | 1170-1184 | 15 | |
| α-helix | 1185-1191 | 7 | |
| α-helix | 1192-1201 | 10 | |
| α-helix | 1207-1218 | 12 | |
| α-helix | 1222-1224 | 3 | |
| α-helix | 1229-1236 | 8 | |
| α-helix | 1262-1269 | 8 | |
| α-helix | 1277-1293 | 17 | |
| α-helix | 1298-1301 | 4 | |
| α-helix | 1304-1309 | 6 | |
| α-helix | 1312-1316 | 5 | |
| α-helix | 1318-1326 | 9 | |
| α-helix | 1331-1346 | 16 | |
| α-helix | 1351-1366 | 16 | |
| α-helix | 1377-1379 | 3 | |
| α-helix | 1380-1389 | 10 | |
| α-helix | 1393-1406 | 14 | |
| α-helix | 1410-1422 | 13 | |
| α-helix | 1426-1439 | 14 | |
| α-helix | 1442-1444 | 3 | |
| α-helix | 1447-1452 | 6 | |
| α-helix | 1456-1469 | 14 | |
| α-helix | 1474-1487 | 14 | |
| α-helix | 1490-1500 | 11 | |
| α-helix | 1506-1523 | 18 | |
| α-helix | 1526-1533 | 8 | |
| α-helix | 1541-1553 | 13 | |
| α-helix | 1557-1579 | 23 | |
| α-helix | 1583-1607 | 25 | |
| α-helix | 1609-1611 | 3 | |
| α-helix | 1612-1623 | 12 | |
| α-helix | 1630-1640 | 11 | |
| α-helix | 1646-1648 | 3 | |
| α-helix | 1650-1661 | 12 | |
| β-strand | 1662 | 1 | 1 |
| β-strand | 1664 | 1 | 1 |
| α-helix | 1666-1677 | 12 | |
| α-helix | 1688-1690 | 3 | |
| α-helix | 1694-1706 | 13 | |
| α-helix | 1710-1727 | 18 | |
| α-helix | 1740-1762 | 23 | |
| α-helix | 1769-1782 | 14 | |
| α-helix | 1787-1811 | 25 | |
| α-helix | 1874-1894 | 21 | |
| α-helix | 1900-1913 | 14 | |
| α-helix | 1917-1929 | 13 | |
| α-helix | 1932-1938 | 7 | |
| α-helix | 1939-1944 | 6 | |
| α-helix | 1951-1967 | 17 | |
| α-helix | 1969-1980 | 12 | |
| α-helix | 1985-1999 | 15 | |
| α-helix | 2003-2020 | 18 | |
| α-helix | 2023-2035 | 13 | |
| α-helix | 2036-2041 | 6 | |
| α-helix | 2044-2059 | 16 | |
| α-helix | 2065-2091 | 27 | |
| α-helix | 2094-2114 | 21 | |
| α-helix | 2115-2117 | 3 | |
| β-strand | 2120-2122 | 3 | 2 |
| α-helix | 2123-2126 | 4 | |
| α-helix | 2128-2132 | 5 | |
| β-strand | 2139 | 1 | 3 |
| α-helix | 2140 | 1 | |
| β-strand | 2152 | 1 | 3 |
| β-strand | 2153-2156 | 4 | 2 |
| β-strand | 2159-2162 | 4 | 2 |
| β-strand | 2170-2176 | 7 | 2 |
| β-strand | 2181-2187 | 7 | 2 |
| α-helix | 2193-2210 | 18 | |
| α-helix | 2213-2217 | 5 | |
| β-strand | 2227-2231 | 5 | 2 |
| β-strand | 2234-2238 | 5 | 2 |
| α-helix | 2239-2240 | 2 | |
| β-strand | 2243-2245 | 3 | 4 |
| α-helix | 2246-2256 | 11 | |
| α-helix | 2263-2271 | 9 | |
| α-helix | 2275-2277 | 3 | |
| α-helix | 2280-2292 | 13 | |
| α-helix | 2298-2305 | 8 | |
| α-helix | 2310-2334 | 25 | |
| β-strand | 2344-2347 | 4 | 4 |
| β-strand | 2353-2355 | 3 | 4 |
| α-helix | 2364-2367 | 4 | |
| α-helix | 2381-2385 | 5 | |
| α-helix | 2395-2409 | 15 | |
| α-helix | 2411-2422 | 12 | |
| α-helix | 2428-2430 | 3 | |
| α-helix | 2495-2507 | 13 | |
| α-helix | 2521-2533 | 13 | |
| α-helix | 2535-2538 | 4 | |
| α-helix | 2543-2545 | 3 | |
Chain B: 116 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 600-609 | 10 | |
| α-helix | 616-629 | 14 | |
| α-helix | 650-665 | 16 | |
| α-helix | 669-678 | 10 | |
| α-helix | 681-683 | 3 | |
| α-helix | 684-687 | 4 | |
| α-helix | 690-699 | 10 | |
| α-helix | 705-718 | 14 | |
| α-helix | 723-743 | 21 | |
| α-helix | 747-763 | 17 | |
| α-helix | 765-768 | 4 | |
| α-helix | 769-771 | 3 | |
| α-helix | 772-780 | 9 | |
| α-helix | 794-809 | 16 | |
| α-helix | 810-813 | 4 | |
| α-helix | 814-824 | 11 | |
| α-helix | 837-851 | 15 | |
| α-helix | 856-860 | 5 | |
| α-helix | 864-874 | 11 | |
| α-helix | 878-891 | 14 | |
| α-helix | 896-902 | 7 | |
| α-helix | 932-935 | 4 | |
| α-helix | 943-960 | 18 | |
| α-helix | 962-964 | 3 | |
| α-helix | 968-982 | 15 | |
| α-helix | 983-989 | 7 | |
| α-helix | 990-1003 | 14 | |
| α-helix | 1009-1023 | 15 | |
| α-helix | 1024-1030 | 7 | |
| α-helix | 1031-1041 | 11 | |
| α-helix | 1049-1063 | 15 | |
| α-helix | 1064-1069 | 6 | |
| α-helix | 1071-1084 | 14 | |
| α-helix | 1088-1090 | 3 | |
| α-helix | 1091-1100 | 10 | |
| α-helix | 1104-1107 | 4 | |
| α-helix | 1111-1123 | 13 | |
| α-helix | 1129-1142 | 14 | |
| α-helix | 1149-1151 | 3 | |
| α-helix | 1153-1165 | 13 | |
| α-helix | 1170-1184 | 15 | |
| α-helix | 1185-1190 | 6 | |
| α-helix | 1192-1201 | 10 | |
| α-helix | 1207-1217 | 11 | |
| α-helix | 1222-1224 | 3 | |
| α-helix | 1229-1237 | 9 | |
| α-helix | 1261-1265 | 5 | |
| α-helix | 1266-1269 | 4 | |
| α-helix | 1277-1293 | 17 | |
| α-helix | 1298-1301 | 4 | |
| α-helix | 1304-1309 | 6 | |
| α-helix | 1311-1316 | 6 | |
| α-helix | 1318-1326 | 9 | |
| α-helix | 1331-1347 | 17 | |
| α-helix | 1351-1365 | 15 | |
| α-helix | 1376-1379 | 4 | |
| α-helix | 1380-1389 | 10 | |
| α-helix | 1393-1406 | 14 | |
| α-helix | 1410-1422 | 13 | |
| α-helix | 1426-1439 | 14 | |
| α-helix | 1447-1452 | 6 | |
| α-helix | 1456-1469 | 14 | |
| α-helix | 1474-1487 | 14 | |
| α-helix | 1490-1498 | 9 | |
| α-helix | 1506-1523 | 18 | |
| α-helix | 1526-1534 | 9 | |
| α-helix | 1541-1553 | 13 | |
| α-helix | 1557-1579 | 23 | |
| α-helix | 1583-1607 | 25 | |
| α-helix | 1609-1611 | 3 | |
| α-helix | 1612-1623 | 12 | |
| α-helix | 1630-1640 | 11 | |
| α-helix | 1650-1661 | 12 | |
| α-helix | 1666-1677 | 12 | |
| α-helix | 1688-1690 | 3 | |
| α-helix | 1694-1706 | 13 | |
| α-helix | 1710-1727 | 18 | |
| α-helix | 1739-1762 | 24 | |
| α-helix | 1769-1782 | 14 | |
| α-helix | 1787-1813 | 27 | |
| α-helix | 1874-1894 | 21 | |
| α-helix | 1900-1913 | 14 | |
| α-helix | 1917-1929 | 13 | |
| α-helix | 1932-1938 | 7 | |
| α-helix | 1939-1944 | 6 | |
| α-helix | 1951-1967 | 17 | |
| α-helix | 1969-1979 | 11 | |
| α-helix | 1985-1998 | 14 | |
| α-helix | 2003-2020 | 18 | |
| α-helix | 2023-2035 | 13 | |
| α-helix | 2036-2041 | 6 | |
| α-helix | 2044-2059 | 16 | |
| α-helix | 2065-2091 | 27 | |
| α-helix | 2094-2114 | 21 | |
| α-helix | 2115-2117 | 3 | |
| β-strand | 2120-2122 | 3 | 5 |
| α-helix | 2123-2126 | 4 | |
| α-helix | 2128-2131 | 4 | |
| β-strand | 2139 | 1 | 6 |
| α-helix | 2140 | 1 | |
| β-strand | 2152 | 1 | 6 |
| β-strand | 2153-2156 | 4 | 5 |
| β-strand | 2159-2162 | 4 | 5 |
| β-strand | 2170-2176 | 7 | 5 |
| β-strand | 2181-2187 | 7 | 5 |
| α-helix | 2193-2211 | 19 | |
| α-helix | 2213-2218 | 6 | |
| β-strand | 2227-2231 | 5 | 5 |
| β-strand | 2234-2238 | 5 | 5 |
| α-helix | 2239-2240 | 2 | |
| β-strand | 2243-2245 | 3 | 7 |
| α-helix | 2246-2256 | 11 | |
| α-helix | 2263-2271 | 9 | |
| α-helix | 2275-2277 | 3 | |
| α-helix | 2280-2293 | 14 | |
| α-helix | 2298-2305 | 8 | |
| α-helix | 2310-2334 | 25 | |
| β-strand | 2344-2347 | 4 | 7 |
| β-strand | 2353-2355 | 3 | 7 |
| α-helix | 2364-2367 | 4 | |
| α-helix | 2381-2385 | 5 | |
| α-helix | 2395-2409 | 15 | |
| α-helix | 2411-2418 | 8 | |
| α-helix | 2428-2430 | 3 | |
| α-helix | 2495-2509 | 15 | |
| α-helix | 2521-2533 | 13 | |
| α-helix | 2535-2538 | 4 | |
| α-helix | 2543-2545 | 3 | |
Chain C: 2 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 14-19 | 6 | 8 |
| β-strand | 23-28 | 6 | 8 |
| β-strand | 33-39 | 7 | 8 |
| β-strand | 47-50 | 4 | 9 |
| β-strand | 56-60 | 5 | 9 |
| β-strand | 65-69 | 5 | 9 |
| β-strand | 79-82 | 4 | 9 |
| β-strand | 88-93 | 6 | 10 |
| β-strand | 99-104 | 6 | 10 |
| β-strand | 108-113 | 6 | 10 |
| β-strand | 123-126 | 4 | 10 |
| β-strand | 131-136 | 6 | 11 |
| β-strand | 142-147 | 6 | 11 |
| β-strand | 152-156 | 5 | 11 |
| β-strand | 162-165 | 4 | 11 |
| α-helix | 171-172 | 2 | |
| β-strand | 173-178 | 6 | 12 |
| β-strand | 184-189 | 6 | 12 |
| β-strand | 194-199 | 6 | 12 |
| β-strand | 210-216 | 7 | 12 |
| β-strand | 223-228 | 6 | 13 |
| β-strand | 234-239 | 6 | 13 |
| β-strand | 243-248 | 6 | 13 |
| β-strand | 253-259 | 7 | 13 |
| α-helix | 265-267 | 3 | |
| β-strand | 273-278 | 6 | 14 |
| β-strand | 284-289 | 6 | 14 |
| β-strand | 293-298 | 6 | 14 |
| β-strand | 304-308 | 5 | 14 |
| β-strand | 315-321 | 7 | 8 |
Chain D: 3 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 14-19 | 6 | 15 |
| β-strand | 23-27 | 5 | 15 |
| β-strand | 34-39 | 6 | 15 |
| β-strand | 48-50 | 3 | 16 |
| β-strand | 56-60 | 5 | 16 |
| β-strand | 65-69 | 5 | 16 |
| β-strand | 79-82 | 4 | 16 |
| β-strand | 88-93 | 6 | 17 |
| β-strand | 99-104 | 6 | 17 |
| β-strand | 108-113 | 6 | 17 |
| β-strand | 123-126 | 4 | 17 |
| β-strand | 131-136 | 6 | 18 |
| β-strand | 142-147 | 6 | 18 |
| β-strand | 152-156 | 5 | 18 |
| β-strand | 162-165 | 4 | 18 |
| α-helix | 172 | 1 | |
| β-strand | 173-178 | 6 | 19 |
| β-strand | 184-189 | 6 | 19 |
| α-helix | 190-192 | 3 | |
| β-strand | 194-199 | 6 | 19 |
| β-strand | 210-216 | 7 | 19 |
| β-strand | 223-228 | 6 | 20 |
| β-strand | 234-239 | 6 | 20 |
| β-strand | 243-248 | 6 | 20 |
| β-strand | 254-259 | 6 | 20 |
| α-helix | 265-267 | 3 | |
| β-strand | 273-278 | 6 | 21 |
| β-strand | 284-289 | 6 | 21 |
| β-strand | 294-298 | 5 | 21 |
| β-strand | 304-308 | 5 | 21 |
| β-strand | 315-321 | 7 | 15 |
Chain E: 83 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 25-27 | 3 | |
| α-helix | 34-46 | 13 | |
| α-helix | 53-70 | 18 | |
| α-helix | 74-77 | 4 | |
| α-helix | 81-91 | 11 | |
| α-helix | 97-110 | 14 | |
| α-helix | 114-121 | 8 | |
| α-helix | 122-124 | 3 | |
| α-helix | 126-134 | 9 | |
| α-helix | 140-157 | 18 | |
| α-helix | 158-160 | 3 | |
| α-helix | 163-179 | 17 | |
| α-helix | 184-197 | 14 | |
| α-helix | 199-204 | 6 | |
| α-helix | 207-215 | 9 | |
| α-helix | 221-236 | 16 | |
| α-helix | 241-243 | 3 | |
| α-helix | 250-254 | 5 | |
| α-helix | 255-258 | 4 | |
| α-helix | 273-292 | 20 | |
| α-helix | 295-302 | 8 | |
| α-helix | 308-316 | 9 | |
| α-helix | 321-334 | 14 | |
| α-helix | 337-341 | 5 | |
| α-helix | 346-351 | 6 | |
| α-helix | 360-362 | 3 | |
| α-helix | 368-376 | 9 | |
| α-helix | 378-379 | 2 | |
| β-strand | 386 | 1 | 22 |
| α-helix | 387-401 | 15 | |
| α-helix | 404-412 | 9 | |
| α-helix | 417-437 | 21 | |
| α-helix | 440-443 | 4 | |
| α-helix | 446-448 | 3 | |
| α-helix | 450-456 | 7 | |
| α-helix | 463-485 | 23 | |
| α-helix | 492-505 | 14 | |
| α-helix | 525-534 | 10 | |
| α-helix | 543-545 | 3 | |
| α-helix | 548-556 | 9 | |
| α-helix | 568-581 | 14 | |
| α-helix | 583-585 | 3 | |
| β-strand | 592 | 1 | 23 |
| α-helix | 598-638 | 41 | |
| α-helix | 651-653 | 3 | |
| β-strand | 654 | 1 | 23 |
| α-helix | 655-658 | 4 | |
| α-helix | 659-667 | 9 | |
| α-helix | 670-678 | 9 | |
| α-helix | 681-688 | 8 | |
| α-helix | 695-704 | 10 | |
| α-helix | 712-722 | 11 | |
| α-helix | 726-741 | 16 | |
| α-helix | 747-759 | 13 | |
| α-helix | 764-777 | 14 | |
| α-helix | 781-790 | 10 | |
| α-helix | 795-797 | 3 | |
| α-helix | 799-805 | 7 | |
| α-helix | 806-810 | 5 | |
| α-helix | 812-819 | 8 | |
| α-helix | 823-830 | 8 | |
| α-helix | 831-835 | 5 | |
| α-helix | 836-851 | 16 | |
| β-strand | 877 | 1 | 22 |
| α-helix | 878-880 | 3 | |
| α-helix | 882-886 | 5 | |
| α-helix | 890-898 | 9 | |
| α-helix | 901-910 | 10 | |
| α-helix | 917-933 | 17 | |
| α-helix | 937-946 | 10 | |
| α-helix | 949-958 | 10 | |
| α-helix | 962-975 | 14 | |
| α-helix | 979-986 | 8 | |
| β-strand | 990-992 | 3 | 24 |
| α-helix | 1002-1005 | 4 | |
| β-strand | 1428-1430 | 3 | 24 |
| α-helix | 1433-1436 | 4 | |
| α-helix | 1445-1447 | 3 | |
| α-helix | 1481-1484 | 4 | |
| α-helix | 1490-1493 | 4 | |
| α-helix | 1525-1528 | 4 | |
| α-helix | 1531-1537 | 7 | |
| α-helix | 1607-1623 | 17 | |
| α-helix | 1629-1642 | 14 | |
| α-helix | 1644-1647 | 4 | |
| α-helix | 1650-1660 | 11 | |
| α-helix | 1667-1675 | 9 | |
| α-helix | 1683-1690 | 8 | |
| α-helix | 1691-1693 | 3 | |
Chain F: 82 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 34-46 | 13 | |
| α-helix | 53-70 | 18 | |
| α-helix | 74-77 | 4 | |
| α-helix | 81-91 | 11 | |
| α-helix | 97-110 | 14 | |
| α-helix | 114-121 | 8 | |
| α-helix | 126-134 | 9 | |
| α-helix | 140-156 | 17 | |
| α-helix | 163-175 | 13 | |
| α-helix | 184-197 | 14 | |
| α-helix | 199-204 | 6 | |
| α-helix | 207-217 | 11 | |
| α-helix | 221-236 | 16 | |
| α-helix | 238-241 | 4 | |
| α-helix | 246-248 | 3 | |
| α-helix | 250-254 | 5 | |
| α-helix | 255-258 | 4 | |
| α-helix | 270-272 | 3 | |
| α-helix | 273-292 | 20 | |
| α-helix | 295-301 | 7 | |
| α-helix | 308-316 | 9 | |
| α-helix | 321-334 | 14 | |
| α-helix | 337-341 | 5 | |
| α-helix | 346-352 | 7 | |
| α-helix | 360-362 | 3 | |
| α-helix | 368-376 | 9 | |
| α-helix | 378-379 | 2 | |
| β-strand | 386 | 1 | 25 |
| α-helix | 387-401 | 15 | |
| α-helix | 404-413 | 10 | |
| α-helix | 417-437 | 21 | |
| α-helix | 440-443 | 4 | |
| α-helix | 444-448 | 5 | |
| α-helix | 450-457 | 8 | |
| α-helix | 463-485 | 23 | |
| α-helix | 492-506 | 15 | |
| α-helix | 525-534 | 10 | |
| α-helix | 543-545 | 3 | |
| α-helix | 548-556 | 9 | |
| α-helix | 568-581 | 14 | |
| α-helix | 588-590 | 3 | |
| β-strand | 592 | 1 | 26 |
| α-helix | 598-611 | 14 | |
| α-helix | 616-638 | 23 | |
| α-helix | 650-653 | 4 | |
| β-strand | 654 | 1 | 26 |
| α-helix | 655-658 | 4 | |
| α-helix | 659-667 | 9 | |
| α-helix | 670-678 | 9 | |
| α-helix | 681-688 | 8 | |
| α-helix | 695-702 | 8 | |
| α-helix | 712-723 | 12 | |
| α-helix | 726-742 | 17 | |
| α-helix | 747-758 | 12 | |
| α-helix | 764-777 | 14 | |
| α-helix | 781-790 | 10 | |
| α-helix | 795-797 | 3 | |
| α-helix | 798-805 | 8 | |
| α-helix | 806-810 | 5 | |
| α-helix | 812-820 | 9 | |
| α-helix | 823-830 | 8 | |
| α-helix | 831-835 | 5 | |
| α-helix | 836-851 | 16 | |
| β-strand | 877 | 1 | 25 |
| α-helix | 878-880 | 3 | |
| α-helix | 882-886 | 5 | |
| α-helix | 890-899 | 10 | |
| α-helix | 901-910 | 10 | |
| α-helix | 917-933 | 17 | |
| α-helix | 937-946 | 10 | |
| α-helix | 949-958 | 10 | |
| α-helix | 962-974 | 13 | |
| α-helix | 975-977 | 3 | |
| α-helix | 979-986 | 8 | |
| β-strand | 990-992 | 3 | 27 |
| β-strand | 1428-1430 | 3 | 27 |
| α-helix | 1433-1437 | 5 | |
| α-helix | 1445-1447 | 3 | |
| α-helix | 1481-1484 | 4 | |
| α-helix | 1489-1493 | 5 | |
| α-helix | 1521-1529 | 9 | |
| α-helix | 1531-1536 | 6 | |
| α-helix | 1607-1622 | 16 | |
| α-helix | 1629-1642 | 14 | |
| α-helix | 1644-1647 | 4 | |
| α-helix | 1650-1659 | 10 | |
| α-helix | 1667-1676 | 10 | |
| α-helix | 1683-1693 | 11 | |
Chain G: 6 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-21 | 15 | |
| α-helix | 26-30 | 5 | |
| α-helix | 70-72 | 3 | |
| β-strand | 104-107 | 4 | 9 |
| α-helix | 120-123 | 4 | |
| α-helix | 133-134 | 2 | |
| α-helix | 139-142 | 4 | |
Chain H: 6 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-21 | 15 | |
| α-helix | 26-30 | 5 | |
| α-helix | 33-36 | 4 | |
| β-strand | 104-107 | 4 | 16 |
| α-helix | 120-123 | 4 | |
| α-helix | 132-134 | 3 | |
| α-helix | 139-141 | 3 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Serine/threonine-protein kinase mTOR | A, B | protein | 2590 | Homo sapiens | P42345 (AlphaFold model) |
| Target of rapamycin complex subunit LST8 | C, D | protein | 326 | Homo sapiens | Q9BVC4 (AlphaFold model) |
| Rapamycin-insensitive companion of mTOR | E, F | protein | 1734 | Homo sapiens | Q6R327 (AlphaFold model) |
| Target of rapamycin complex 2 subunit MAPKAP1 | G, H | protein | 522 | Homo sapiens | Q9BPZ7 (AlphaFold model) |
Sequence of entity 1 (A, B), FASTA
>9T7J_1 Serine/threonine-protein kinase mTOR (chains A, B)
MASWSHPQFEKGGGARGGSGGGSWSHPQFEKGENLYFQGGTMLGTGPAAATTAATTSSNV
SVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSD
ANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLAMAGDT
FTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVW
DPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDD
RIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSF
QAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLK
CRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGL
LSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQ
DIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPK
GLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIR
MEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASL
DERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILT
ELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVL
ATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYR
KYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSE
SKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIF
KSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMR
EFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAA
IQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPI
VRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKG
YTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDD
WLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIR
SIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHY
KELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDA
LVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAA
AWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMA
GESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMV
RSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYA
YMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQL
NLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRH
ASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLM
YTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVI
PQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMC
EHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMME
RGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLT
SLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNG
HEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGW
VPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDL
AKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFG
DCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLE
AFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESI
HSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLC
QCYIGWCPFW
Sequence of entity 2 (C, D), FASTA
>9T7J_2 Target of rapamycin complex subunit LST8 (chains C, D)
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA
GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ
CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP
DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE
TGEIKREYGGHQKAVVCLAFNDSVLG
Sequence of entity 3 (E, F), FASTA
>9T7J_3 Rapamycin-insensitive companion of mTOR (chains E, F)
MADYKDHDGDYKDHDIDYKDDDDKGTMAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREP
SDNLREILQNVARLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLN
EAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMI
TVNASLFPSSVTNSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILKN
VIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHSPDTAEGQLK
EDREARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDI
FRLPLPVVTEEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLAL
ILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMN
MAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQKAIATHQKRDQYLRV
QKDIFILKDTEEALLINLRDSQVLQHKENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFV
RRLLYFYKPSSKLYANLDLDFAKAKQLTVVGCQFTEFLLESEEDGQGYLEDLVKDIVQWL
NASSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQ
DHLLKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIEL
LVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKG
FSYLNERGYVAKQLEKWHREYNSKYVDLIEEQLNEALTTYRKPVDGDNYVRRSNQRLQRP
HVYLPIHLYGQLVHHKTGCHLLEVQNIITELCRNVRTPDLDKWEEIKKLKASLWALGNIG
SSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHNWDAVR
HSRKHLWPVVPDDVEQLCNELSSIPSTLSLNSESTSSRHNSESESVPSSMFILEDDRFGS
SSTSTFFLDINEDTEPTFYDRSGPIKDKNSFPFFASSKLVKNRILNSLTLPNKKHRSSSD
PKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTPISTVQKTLQLETSFMGNKHIEDTGS
TPSIGENDLKFTKNFGTENHRENTSRERLVVESSTSSHMKIRSQSFNTDTTTSGISSMSS
SPSRETVGVDATTMDTDCGSMSTVVSTKTIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSH
TLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHSEALASP
AKDVLFTDTITMKANSFESRLTPSRFMKALSYASLDKEDLLSPINQNTLQRSSSVRSMVS
SATYGGSDDYIGLALPVDINDIFQVKDIPYFQTKNIPPHDDRGARAFAHDAGGLPSGTGG
LVKNSFHLLRQQMSLTEIMNSIHSDASLFLESTEDTGLQEHTDDNCLYCVCIEILGFQPS
NQLSAICSHSDFQDIPYSDWCEQTIHNPLEVVPSKFSGISGCSDGVSQEGSASSTKSTEL
LLGVKTIPDDTPMCRILLRKEVLRLVINLSSSVSTKCHETGLLTIKEKYPQTFDDICLYS
EVSHLLSHCTFRLPCRRFIQELFQDVQFLQMHEEAEAVLATPPKQPIVDTSAES
Sequence of entity 4 (G, H), FASTA
>9T7J_4 Target of rapamycin complex 2 subunit MAPKAP1 (chains G, H)
XAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE
TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL
KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY
LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE
VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT
MKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRAD
GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS
TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL
KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 2 |
| ZN | Zinc ion | Zn | 2 |
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 2 |
| IHP | Inositol hexakisphosphate | C6 H18 O24 P6 | 2 |
Primary citation
Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop. Hay, I.M., Bourguet, M., Ahsan, B. et al. bioRxiv (2026). DOI 10.64898/2026.01.08.698367
Other PDB entries of the same protein (UniProt P42345 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4DRI 1.45 Å, Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of…
- 9DBO 1.55 Å, Crystal structure of a synthetic Fab (R3E9) in complex with the FRB domain of mTOR
- 5GPG 1.67 Å, Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB…
- 5WBH 1.75 Å, Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1
- 4DRJ 1.8 Å, o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
- 3FAP 1.85 Å, Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb…
- 8PPZ 1.85 Å, Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
- 8XI9 1.85 Å, Crystal structure of FRB-FKBP fusion protein in complex with rapamycin
- 9PIW 1.9 Å, Crystal structure of a synthetic Fab (1A) in complex with the FRB domain of mTOR
- 9DL0 2.0 Å, Crystal structure of a synthetic Fab (R3H8) in complex with the FRB domain of mTOR
- 9PJ1 2.05 Å, Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of…
- 9PIU 2.18 Å, Crystal structure of a synthetic Fab (2C) in complex with the FRB domain of mTOR
Browse structure collections
About this viewer
MolViewer shows 9T7J directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.