6ZWM: Human mTOR complex 2, overall refinement
cryo-EM structure of human mTOR complex 2, overall refinement. Determined by electron microscopy at 3.2 Å resolution. Released 18 Nov 2020.
- Method
- Electron microscopy
- Resolution
- 3.2 Å
- Organism
- Homo sapiens
- Chains
- 8
- Atoms
- 56,947
- Mol. weight
- 1157.33 kDa
- Ligands
- AGS, IHP, ACE, ZN
- Released
- 18 Nov 2020
Explore 6ZWM in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6ZWM contains 426 α-helices and 94 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 130 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-29 | 11 | |
| α-helix | 38-52 | 15 | |
| α-helix | 61-73 | 13 | |
| α-helix | 83-92 | 10 | |
| α-helix | 102-114 | 13 | |
| α-helix | 122-134 | 13 | |
| α-helix | 141-155 | 15 | |
| α-helix | 165-178 | 14 | |
| α-helix | 182-185 | 4 | |
| α-helix | 188-197 | 10 | |
| α-helix | 204-222 | 19 | |
| α-helix | 234-245 | 12 | |
| α-helix | 262-275 | 14 | |
| α-helix | 278-286 | 9 | |
| α-helix | 363-375 | 13 | |
| α-helix | 387-402 | 16 | |
| α-helix | 411-423 | 13 | |
| α-helix | 430-443 | 14 | |
| α-helix | 448-451 | 4 | |
| α-helix | 452-460 | 9 | |
| α-helix | 480-490 | 11 | |
| α-helix | 501-511 | 11 | |
| α-helix | 515-527 | 13 | |
| α-helix | 533-548 | 16 | |
| α-helix | 582-589 | 8 | |
| α-helix | 601-606 | 6 | |
| α-helix | 609-612 | 4 | |
| α-helix | 616-628 | 13 | |
| α-helix | 648-665 | 18 | |
| α-helix | 669-678 | 10 | |
| α-helix | 681-683 | 3 | |
| α-helix | 684-687 | 4 | |
| α-helix | 690-700 | 11 | |
| α-helix | 705-718 | 14 | |
| α-helix | 723-742 | 20 | |
| α-helix | 747-763 | 17 | |
| α-helix | 765-768 | 4 | |
| α-helix | 772-783 | 12 | |
| α-helix | 793-808 | 16 | |
| α-helix | 817-828 | 12 | |
| α-helix | 838-846 | 9 | |
| α-helix | 856-860 | 5 | |
| α-helix | 864-870 | 7 | |
| α-helix | 878-891 | 14 | |
| α-helix | 896-901 | 6 | |
| α-helix | 929-935 | 7 | |
| α-helix | 943-945 | 3 | |
| α-helix | 947-959 | 13 | |
| α-helix | 968-982 | 15 | |
| α-helix | 990-1003 | 14 | |
| α-helix | 1006-1008 | 3 | |
| α-helix | 1009-1022 | 14 | |
| α-helix | 1028-1030 | 3 | |
| α-helix | 1031-1038 | 8 | |
| α-helix | 1049-1063 | 15 | |
| α-helix | 1067-1069 | 3 | |
| α-helix | 1072-1074 | 3 | |
| α-helix | 1075-1083 | 9 | |
| α-helix | 1091-1100 | 10 | |
| α-helix | 1116-1119 | 4 | |
| α-helix | 1129-1141 | 13 | |
| α-helix | 1153-1163 | 11 | |
| α-helix | 1170-1181 | 12 | |
| α-helix | 1192-1202 | 11 | |
| α-helix | 1207-1217 | 11 | |
| α-helix | 1229-1237 | 9 | |
| α-helix | 1266-1269 | 4 | |
| α-helix | 1277-1293 | 17 | |
| α-helix | 1298-1307 | 10 | |
| α-helix | 1311-1316 | 6 | |
| α-helix | 1318-1326 | 9 | |
| α-helix | 1331-1347 | 17 | |
| α-helix | 1351-1365 | 15 | |
| α-helix | 1371-1373 | 3 | |
| α-helix | 1377-1379 | 3 | |
| α-helix | 1380-1389 | 10 | |
| α-helix | 1393-1406 | 14 | |
| α-helix | 1410-1422 | 13 | |
| α-helix | 1426-1438 | 13 | |
| α-helix | 1447-1452 | 6 | |
| α-helix | 1456-1469 | 14 | |
| α-helix | 1477-1487 | 11 | |
| α-helix | 1490-1498 | 9 | |
| α-helix | 1506-1523 | 18 | |
| α-helix | 1526-1533 | 8 | |
| α-helix | 1541-1553 | 13 | |
| α-helix | 1559-1578 | 20 | |
| α-helix | 1583-1597 | 15 | |
| α-helix | 1599-1607 | 9 | |
| α-helix | 1612-1623 | 12 | |
| α-helix | 1630-1640 | 11 | |
| α-helix | 1651-1662 | 12 | |
| α-helix | 1666-1677 | 12 | |
| α-helix | 1688-1690 | 3 | |
| α-helix | 1694-1707 | 14 | |
| α-helix | 1712-1725 | 14 | |
| α-helix | 1728-1730 | 3 | |
| α-helix | 1740-1762 | 23 | |
| α-helix | 1769-1783 | 15 | |
| α-helix | 1787-1807 | 21 | |
| α-helix | 1876-1895 | 20 | |
| α-helix | 1900-1913 | 14 | |
| α-helix | 1919-1929 | 11 | |
| α-helix | 1933-1938 | 6 | |
| α-helix | 1939-1943 | 5 | |
| α-helix | 1951-1967 | 17 | |
| α-helix | 1973-1980 | 8 | |
| α-helix | 1985-1998 | 14 | |
| α-helix | 2004-2016 | 13 | |
| α-helix | 2023-2041 | 19 | |
| α-helix | 2044-2058 | 15 | |
| α-helix | 2065-2090 | 26 | |
| α-helix | 2094-2112 | 19 | |
| β-strand | 2120-2122 | 3 | 1 |
| α-helix | 2123-2126 | 4 | |
| β-strand | 2139 | 1 | 2 |
| α-helix | 2140 | 1 | |
| β-strand | 2152 | 1 | 2 |
| β-strand | 2153-2156 | 4 | 3 |
| β-strand | 2159-2161 | 3 | 1 |
| β-strand | 2170 | 1 | 4 |
| β-strand | 2173-2176 | 4 | 3 |
| β-strand | 2181-2183 | 3 | 3 |
| β-strand | 2184-2188 | 5 | 4 |
| α-helix | 2193-2210 | 18 | |
| α-helix | 2213-2216 | 4 | |
| β-strand | 2227-2229 | 3 | 4 |
| β-strand | 2234-2238 | 5 | 4 |
| α-helix | 2239-2240 | 2 | |
| β-strand | 2243-2245 | 3 | 5 |
| α-helix | 2247-2256 | 10 | |
| α-helix | 2263-2271 | 9 | |
| α-helix | 2280-2292 | 13 | |
| α-helix | 2298-2305 | 8 | |
| α-helix | 2310-2334 | 25 | |
| β-strand | 2344-2347 | 4 | 5 |
| β-strand | 2353-2355 | 3 | 5 |
| α-helix | 2381-2384 | 4 | |
| α-helix | 2395-2409 | 15 | |
| α-helix | 2411-2422 | 12 | |
| α-helix | 2494-2507 | 14 | |
| α-helix | 2521-2532 | 12 | |
| α-helix | 2535-2538 | 4 | |
| α-helix | 2543-2545 | 3 | |
Chain B: 132 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-29 | 11 | |
| α-helix | 38-52 | 15 | |
| α-helix | 61-73 | 13 | |
| α-helix | 83-93 | 11 | |
| α-helix | 102-113 | 12 | |
| α-helix | 122-134 | 13 | |
| α-helix | 141-155 | 15 | |
| α-helix | 165-178 | 14 | |
| α-helix | 180-183 | 4 | |
| α-helix | 188-197 | 10 | |
| α-helix | 204-222 | 19 | |
| α-helix | 234-245 | 12 | |
| α-helix | 259-275 | 17 | |
| α-helix | 278-286 | 9 | |
| α-helix | 363-375 | 13 | |
| α-helix | 387-402 | 16 | |
| α-helix | 411-422 | 12 | |
| α-helix | 430-443 | 14 | |
| α-helix | 448-451 | 4 | |
| α-helix | 452-460 | 9 | |
| α-helix | 480-490 | 11 | |
| α-helix | 501-511 | 11 | |
| α-helix | 515-527 | 13 | |
| α-helix | 533-548 | 16 | |
| α-helix | 580-591 | 12 | |
| α-helix | 602-606 | 5 | |
| α-helix | 609-612 | 4 | |
| α-helix | 616-629 | 14 | |
| α-helix | 649-665 | 17 | |
| α-helix | 669-677 | 9 | |
| α-helix | 681-683 | 3 | |
| α-helix | 690-700 | 11 | |
| α-helix | 705-717 | 13 | |
| α-helix | 723-743 | 21 | |
| α-helix | 747-763 | 17 | |
| α-helix | 765-768 | 4 | |
| α-helix | 772-783 | 12 | |
| α-helix | 793-808 | 16 | |
| α-helix | 817-828 | 12 | |
| α-helix | 838-846 | 9 | |
| α-helix | 856-860 | 5 | |
| α-helix | 864-870 | 7 | |
| α-helix | 878-891 | 14 | |
| α-helix | 896-901 | 6 | |
| α-helix | 930-935 | 6 | |
| α-helix | 943-945 | 3 | |
| α-helix | 947-959 | 13 | |
| α-helix | 968-982 | 15 | |
| α-helix | 990-1003 | 14 | |
| α-helix | 1009-1022 | 14 | |
| α-helix | 1028-1030 | 3 | |
| α-helix | 1031-1038 | 8 | |
| α-helix | 1049-1063 | 15 | |
| α-helix | 1067-1069 | 3 | |
| α-helix | 1072-1074 | 3 | |
| α-helix | 1075-1083 | 9 | |
| α-helix | 1091-1100 | 10 | |
| α-helix | 1116-1122 | 7 | |
| α-helix | 1129-1141 | 13 | |
| α-helix | 1142-1144 | 3 | |
| α-helix | 1153-1163 | 11 | |
| α-helix | 1170-1181 | 12 | |
| α-helix | 1186-1188 | 3 | |
| α-helix | 1192-1201 | 10 | |
| α-helix | 1207-1217 | 11 | |
| α-helix | 1229-1237 | 9 | |
| α-helix | 1266-1269 | 4 | |
| α-helix | 1277-1293 | 17 | |
| α-helix | 1298-1307 | 10 | |
| α-helix | 1311-1316 | 6 | |
| α-helix | 1318-1326 | 9 | |
| α-helix | 1331-1347 | 17 | |
| α-helix | 1351-1365 | 15 | |
| α-helix | 1371-1373 | 3 | |
| α-helix | 1377-1379 | 3 | |
| α-helix | 1380-1388 | 9 | |
| α-helix | 1393-1406 | 14 | |
| α-helix | 1410-1422 | 13 | |
| α-helix | 1426-1438 | 13 | |
| α-helix | 1447-1452 | 6 | |
| α-helix | 1456-1467 | 12 | |
| α-helix | 1477-1487 | 11 | |
| α-helix | 1490-1498 | 9 | |
| α-helix | 1506-1523 | 18 | |
| α-helix | 1526-1533 | 8 | |
| α-helix | 1541-1553 | 13 | |
| α-helix | 1559-1578 | 20 | |
| α-helix | 1583-1597 | 15 | |
| α-helix | 1599-1607 | 9 | |
| α-helix | 1612-1623 | 12 | |
| α-helix | 1630-1640 | 11 | |
| α-helix | 1651-1662 | 12 | |
| α-helix | 1666-1677 | 12 | |
| α-helix | 1688-1690 | 3 | |
| α-helix | 1694-1707 | 14 | |
| α-helix | 1712-1725 | 14 | |
| α-helix | 1728-1730 | 3 | |
| α-helix | 1740-1762 | 23 | |
| α-helix | 1769-1783 | 15 | |
| α-helix | 1787-1808 | 22 | |
| α-helix | 1874-1895 | 22 | |
| α-helix | 1900-1913 | 14 | |
| α-helix | 1919-1929 | 11 | |
| α-helix | 1933-1938 | 6 | |
| α-helix | 1939-1943 | 5 | |
| α-helix | 1951-1967 | 17 | |
| α-helix | 1973-1980 | 8 | |
| α-helix | 1985-1998 | 14 | |
| α-helix | 2004-2016 | 13 | |
| α-helix | 2023-2041 | 19 | |
| α-helix | 2044-2058 | 15 | |
| α-helix | 2065-2074 | 10 | |
| α-helix | 2077-2090 | 14 | |
| α-helix | 2094-2112 | 19 | |
| β-strand | 2120-2122 | 3 | 6 |
| α-helix | 2123-2126 | 4 | |
| β-strand | 2139 | 1 | 7 |
| α-helix | 2140 | 1 | |
| β-strand | 2152 | 1 | 7 |
| β-strand | 2153-2156 | 4 | 8 |
| β-strand | 2159-2162 | 4 | 6 |
| β-strand | 2170-2171 | 2 | 6 |
| β-strand | 2173-2176 | 4 | 8 |
| β-strand | 2181-2183 | 3 | 8 |
| β-strand | 2184-2188 | 5 | 6 |
| α-helix | 2193-2210 | 18 | |
| α-helix | 2213-2216 | 4 | |
| β-strand | 2227-2229 | 3 | 6 |
| β-strand | 2234-2238 | 5 | 6 |
| α-helix | 2239-2240 | 2 | |
| β-strand | 2243-2245 | 3 | 9 |
| α-helix | 2247-2256 | 10 | |
| α-helix | 2263-2271 | 9 | |
| α-helix | 2275-2277 | 3 | |
| α-helix | 2280-2292 | 13 | |
| α-helix | 2298-2305 | 8 | |
| α-helix | 2310-2334 | 25 | |
| β-strand | 2344-2347 | 4 | 9 |
| β-strand | 2353-2355 | 3 | 9 |
| α-helix | 2381-2384 | 4 | |
| α-helix | 2395-2409 | 15 | |
| α-helix | 2411-2422 | 12 | |
| α-helix | 2495-2507 | 13 | |
| α-helix | 2521-2532 | 12 | |
| α-helix | 2535-2538 | 4 | |
| α-helix | 2543-2545 | 3 | |
Chain C: 0 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 14-19 | 6 | 10 |
| β-strand | 23-27 | 5 | 10 |
| β-strand | 34-39 | 6 | 10 |
| β-strand | 47-50 | 4 | 11 |
| β-strand | 56-60 | 5 | 11 |
| β-strand | 65-69 | 5 | 11 |
| β-strand | 79-81 | 3 | 11 |
| β-strand | 88-93 | 6 | 12 |
| β-strand | 99-104 | 6 | 12 |
| β-strand | 108-113 | 6 | 12 |
| β-strand | 124-126 | 3 | 12 |
| β-strand | 131-136 | 6 | 13 |
| β-strand | 142-147 | 6 | 13 |
| β-strand | 152-156 | 5 | 13 |
| β-strand | 162-165 | 4 | 13 |
| β-strand | 173-177 | 5 | 14 |
| β-strand | 185-189 | 5 | 14 |
| β-strand | 194-198 | 5 | 14 |
| β-strand | 211-216 | 6 | 14 |
| β-strand | 223-228 | 6 | 15 |
| β-strand | 234-239 | 6 | 15 |
| β-strand | 243-248 | 6 | 15 |
| β-strand | 254-259 | 6 | 15 |
| β-strand | 273-277 | 5 | 16 |
| β-strand | 284-289 | 6 | 16 |
| β-strand | 293-298 | 6 | 16 |
| β-strand | 304-308 | 5 | 16 |
| β-strand | 315-321 | 7 | 10 |
Chain D: 0 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 14-19 | 6 | 17 |
| β-strand | 23-27 | 5 | 17 |
| β-strand | 34-39 | 6 | 17 |
| β-strand | 47-50 | 4 | 18 |
| β-strand | 56-60 | 5 | 18 |
| β-strand | 64-69 | 6 | 18 |
| β-strand | 79-82 | 4 | 18 |
| β-strand | 88-93 | 6 | 19 |
| β-strand | 99-104 | 6 | 19 |
| β-strand | 108-113 | 6 | 19 |
| β-strand | 124-126 | 3 | 19 |
| β-strand | 131-136 | 6 | 20 |
| β-strand | 142-147 | 6 | 20 |
| β-strand | 152-156 | 5 | 20 |
| β-strand | 162-165 | 4 | 20 |
| β-strand | 173-178 | 6 | 21 |
| β-strand | 185-189 | 5 | 21 |
| β-strand | 193-198 | 6 | 21 |
| β-strand | 211-217 | 7 | 21 |
| β-strand | 223-228 | 6 | 22 |
| β-strand | 234-239 | 6 | 22 |
| β-strand | 243-248 | 6 | 22 |
| β-strand | 254-259 | 6 | 22 |
| β-strand | 273-277 | 5 | 23 |
| β-strand | 284-289 | 6 | 23 |
| β-strand | 294-298 | 5 | 23 |
| β-strand | 304-308 | 5 | 23 |
| β-strand | 315-321 | 7 | 17 |
Chain E: 77 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 33-45 | 13 | |
| α-helix | 46-48 | 3 | |
| α-helix | 53-69 | 17 | |
| α-helix | 74-77 | 4 | |
| α-helix | 81-88 | 8 | |
| α-helix | 97-110 | 14 | |
| α-helix | 114-122 | 9 | |
| α-helix | 125-133 | 9 | |
| α-helix | 142-156 | 15 | |
| α-helix | 163-174 | 12 | |
| α-helix | 184-197 | 14 | |
| α-helix | 199-204 | 6 | |
| α-helix | 208-213 | 6 | |
| α-helix | 221-234 | 14 | |
| α-helix | 238-241 | 4 | |
| α-helix | 250-252 | 3 | |
| α-helix | 255-258 | 4 | |
| α-helix | 274-291 | 18 | |
| α-helix | 295-301 | 7 | |
| α-helix | 310-314 | 5 | |
| α-helix | 323-334 | 12 | |
| α-helix | 337-341 | 5 | |
| α-helix | 346-352 | 7 | |
| α-helix | 360-362 | 3 | |
| α-helix | 370-376 | 7 | |
| α-helix | 378-379 | 2 | |
| α-helix | 387-401 | 15 | |
| α-helix | 404-413 | 10 | |
| α-helix | 417-437 | 21 | |
| α-helix | 440-443 | 4 | |
| α-helix | 450-456 | 7 | |
| α-helix | 463-485 | 23 | |
| α-helix | 492-508 | 17 | |
| α-helix | 526-534 | 9 | |
| α-helix | 548-556 | 9 | |
| α-helix | 568-581 | 14 | |
| α-helix | 588-590 | 3 | |
| β-strand | 592 | 1 | 24 |
| α-helix | 599-611 | 13 | |
| α-helix | 623-638 | 16 | |
| α-helix | 648-651 | 4 | |
| β-strand | 654 | 1 | 24 |
| α-helix | 655-658 | 4 | |
| α-helix | 659-667 | 9 | |
| α-helix | 670-678 | 9 | |
| α-helix | 682-688 | 7 | |
| α-helix | 696-702 | 7 | |
| α-helix | 712-722 | 11 | |
| α-helix | 726-734 | 9 | |
| α-helix | 738-741 | 4 | |
| α-helix | 747-759 | 13 | |
| α-helix | 764-777 | 14 | |
| α-helix | 781-789 | 9 | |
| α-helix | 799-806 | 8 | |
| α-helix | 807-810 | 4 | |
| α-helix | 812-820 | 9 | |
| α-helix | 824-830 | 7 | |
| α-helix | 831-835 | 5 | |
| α-helix | 836-851 | 16 | |
| α-helix | 877-880 | 4 | |
| α-helix | 882-886 | 5 | |
| α-helix | 892-897 | 6 | |
| α-helix | 902-910 | 9 | |
| α-helix | 917-933 | 17 | |
| α-helix | 937-944 | 8 | |
| α-helix | 949-958 | 10 | |
| α-helix | 962-974 | 13 | |
| α-helix | 979-987 | 9 | |
| β-strand | 990-992 | 3 | 25 |
| α-helix | 1002-1004 | 3 | |
| β-strand | 1428-1430 | 3 | 25 |
| α-helix | 1433-1435 | 3 | |
| α-helix | 1480-1483 | 4 | |
| α-helix | 1489-1493 | 5 | |
| α-helix | 1525-1529 | 5 | |
| α-helix | 1531-1537 | 7 | |
| α-helix | 1610-1622 | 13 | |
| α-helix | 1629-1642 | 14 | |
| α-helix | 1650-1660 | 11 | |
| α-helix | 1667-1676 | 10 | |
| α-helix | 1683-1693 | 11 | |
Chain F: 77 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 33-45 | 13 | |
| α-helix | 46-48 | 3 | |
| α-helix | 53-69 | 17 | |
| α-helix | 81-89 | 9 | |
| α-helix | 97-108 | 12 | |
| α-helix | 114-122 | 9 | |
| α-helix | 126-133 | 8 | |
| α-helix | 142-156 | 15 | |
| α-helix | 158-160 | 3 | |
| α-helix | 163-174 | 12 | |
| α-helix | 184-195 | 12 | |
| α-helix | 199-204 | 6 | |
| α-helix | 208-214 | 7 | |
| α-helix | 221-234 | 14 | |
| α-helix | 238-241 | 4 | |
| α-helix | 250-254 | 5 | |
| α-helix | 255-258 | 4 | |
| α-helix | 274-291 | 18 | |
| α-helix | 295-301 | 7 | |
| α-helix | 310-314 | 5 | |
| α-helix | 324-334 | 11 | |
| α-helix | 337-339 | 3 | |
| α-helix | 346-352 | 7 | |
| α-helix | 360-362 | 3 | |
| α-helix | 370-376 | 7 | |
| α-helix | 378-379 | 2 | |
| α-helix | 387-401 | 15 | |
| α-helix | 404-413 | 10 | |
| α-helix | 417-437 | 21 | |
| α-helix | 440-443 | 4 | |
| α-helix | 450-456 | 7 | |
| α-helix | 463-485 | 23 | |
| α-helix | 493-508 | 16 | |
| α-helix | 526-534 | 9 | |
| α-helix | 548-556 | 9 | |
| α-helix | 568-581 | 14 | |
| α-helix | 591 | 1 | |
| β-strand | 592 | 1 | 26 |
| α-helix | 599-613 | 15 | |
| α-helix | 623-638 | 16 | |
| α-helix | 648-651 | 4 | |
| β-strand | 654 | 1 | 26 |
| α-helix | 655-658 | 4 | |
| α-helix | 659-667 | 9 | |
| α-helix | 670-678 | 9 | |
| α-helix | 682-688 | 7 | |
| α-helix | 696-702 | 7 | |
| α-helix | 712-722 | 11 | |
| α-helix | 726-734 | 9 | |
| α-helix | 737-741 | 5 | |
| α-helix | 747-758 | 12 | |
| α-helix | 764-777 | 14 | |
| α-helix | 781-788 | 8 | |
| α-helix | 799-805 | 7 | |
| α-helix | 806-810 | 5 | |
| α-helix | 812-820 | 9 | |
| α-helix | 824-830 | 7 | |
| α-helix | 831-835 | 5 | |
| α-helix | 836-851 | 16 | |
| α-helix | 877-880 | 4 | |
| α-helix | 882-886 | 5 | |
| α-helix | 892-897 | 6 | |
| α-helix | 902-910 | 9 | |
| α-helix | 918-933 | 16 | |
| α-helix | 937-943 | 7 | |
| α-helix | 949-958 | 10 | |
| α-helix | 962-975 | 14 | |
| α-helix | 979-987 | 9 | |
| β-strand | 990-992 | 3 | 27 |
| α-helix | 1002-1004 | 3 | |
| β-strand | 1428-1430 | 3 | 27 |
| α-helix | 1433-1435 | 3 | |
| α-helix | 1480-1483 | 4 | |
| α-helix | 1489-1492 | 4 | |
| α-helix | 1525-1528 | 4 | |
| α-helix | 1531-1537 | 7 | |
| α-helix | 1610-1622 | 13 | |
| α-helix | 1629-1642 | 14 | |
| α-helix | 1650-1660 | 11 | |
| α-helix | 1667-1676 | 10 | |
| α-helix | 1683-1693 | 11 | |
Chain G: 5 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-20 | 14 | |
| α-helix | 26-30 | 5 | |
| α-helix | 85-100 | 16 | |
| β-strand | 104-106 | 3 | 11 |
| α-helix | 117-123 | 7 | |
| α-helix | 140-145 | 6 | |
Chain H: 5 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-20 | 14 | |
| α-helix | 27-30 | 4 | |
| α-helix | 85-100 | 16 | |
| β-strand | 104-106 | 3 | 18 |
| α-helix | 117-123 | 7 | |
| α-helix | 140-145 | 6 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Serine/threonine-protein kinase mTOR | A, B | protein | 2549 | Homo sapiens | P42345 (AlphaFold model) |
| Target of rapamycin complex subunit LST8 | C, D | protein | 326 | Homo sapiens | Q9BVC4 (AlphaFold model) |
| Rapamycin-insensitive companion of mTOR | E, F | protein | 1708 | Homo sapiens | Q6R327 (AlphaFold model) |
| Target of rapamycin complex 2 subunit MAPKAP1 | G, H | protein | 522 | Homo sapiens | Q9BPZ7 (AlphaFold model) |
Sequence of entity 1 (A, B), FASTA
>6ZWM_1 Serine/threonine-protein kinase mTOR (chains A, B)
MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP
TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC
HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG
VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
VPTQVELLIKQATSHENLCQCYIGWCPFW
Sequence of entity 2 (C, D), FASTA
>6ZWM_2 Target of rapamycin complex subunit LST8 (chains C, D)
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA
GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ
CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP
DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE
TGEIKREYGGHQKAVVCLAFNDSVLG
Sequence of entity 3 (E, F), FASTA
>6ZWM_3 Rapamycin-insensitive companion of mTOR (chains E, F)
MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL
NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV
LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER
DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT
RQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIIN
LCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTEEFIEALLSVDPGRFQD
SWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHIS
VRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLKRFH
EMKKRGPKPYSLHLDHIIQKAIATHQKRDQYLRVQKDIFILKDTEEALLINLRDSQVLQH
KENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYANLDLDFAKAKQ
LTVVGCQFTEFLLESEEDGQGYLEDLVKDIVQWLNASSGMKPERSLQNNGLLTTLSQHYF
LFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKI
LTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACED
KANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKYV
DLIEEQLNEALTTYRKPVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEVQN
IITELCRNVRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCE
VLSIRGTCVYVLGLIAKTKQGCDILKCHNWDAVRHSRKHLWPVVPDDVEQLCNELSSIPS
TLSLNSESTSSRHNSESESVPSSMFILEDDRFGSSSTSTFFLDINEDTEPTFYDRSGPIK
DKNSFPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVD
FNHSDDFTPISTVQKTLQLETSFMGNKHIEDTGSTPSIGENDLKFTKNFGTENHRENTSR
ERLVVESSTSSHMKIRSQSFNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMSTVVS
TKTIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFS
YTSSRDAFGYATLKRLQQQRMHPSLSHSEALASPAKDVLFTDTITMKANSFESRLTPSRF
MKALSYASLDKEDLLSPINQNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQVK
DIPYFQTKNIPPHDDRGARAFAHDAGGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDA
SLFLESTEDTGLQEHTDDNCLYCVCIEILGFQPSNQLSAICSHSDFQDIPYSDWCEQTIH
NPLEVVPSKFSGISGCSDGVSQEGSASSTKSTELLLGVKTIPDDTPMCRILLRKEVLRLV
INLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDV
QFLQMHEEAEAVLATPPKQPIVDTSAES
Sequence of entity 4 (G, H), FASTA
>6ZWM_4 Target of rapamycin complex 2 subunit MAPKAP1 (chains G, H)
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE
TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL
KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY
LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE
VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT
MKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRAD
GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS
TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL
KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| AGS | Phosphothiophosphoric acid-adenylate ester | C10 H16 N5 O12 P3 S | 4 |
| IHP | Inositol hexakisphosphate | C6 H18 O24 P6 | 2 |
| ACE | Acetyl group | C2 H4 O | 2 |
| ZN | Zinc ion | Zn | 2 |
Primary citation
The 3.2- angstrom resolution structure of human mTORC2. Scaiola, A., Mangia, F., Imseng, S. et al. Sci Adv (2020) 6. DOI 10.1126/sciadv.abc1251 · PubMed
Other PDB entries of the same protein (UniProt P42345 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4DRI 1.45 Å, Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of…
- 9DBO 1.55 Å, Crystal structure of a synthetic Fab (R3E9) in complex with the FRB domain of mTOR
- 5GPG 1.67 Å, Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB…
- 5WBH 1.75 Å, Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1
- 4DRJ 1.8 Å, o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
- 3FAP 1.85 Å, Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb…
- 8PPZ 1.85 Å, Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
- 8XI9 1.85 Å, Crystal structure of FRB-FKBP fusion protein in complex with rapamycin
- 9PIW 1.9 Å, Crystal structure of a synthetic Fab (1A) in complex with the FRB domain of mTOR
- 9DL0 2.0 Å, Crystal structure of a synthetic Fab (R3H8) in complex with the FRB domain of mTOR
- 9PJ1 2.05 Å, Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of…
- 9PIU 2.18 Å, Crystal structure of a synthetic Fab (2C) in complex with the FRB domain of mTOR
Browse structure collections
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