Spliceosome-associated protein CWC27 homolog (CWC27) is a 472-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6UX04.
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The mean pLDDT of this model is 73.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 41% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)
Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2HQ6 | X-ray | 1.75 Å | A=8-173 |
| 4R3E | X-ray | 2.0 Å | A=1-178 |
| 7DVQ | EM | 2.89 Å | z=1-472 |
| 8I0R | EM | 3.0 Å | z=1-472 |
| 6YVH | X-ray | 3.19 Å | C/E/G/I=378-431 |
| 6FF7 | EM | 4.5 Å | s=1-472 |
| 5Z58 | EM | 4.9 Å | z=1-472 |
| 5Z56 | EM | 5.1 Å | z=1-472 |
| 6FF4 | EM | 16.0 Å | s=1-472 |
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