6FF7: Human Bact spliceosome core structure
human Bact spliceosome core structure. Determined by electron microscopy at 4.5 Å resolution. Released 13 Mar 2019.
- Method
- Electron microscopy
- Resolution
- 4.5 Å
- Organism
- Homo sapiens
- Chains
- 61
- Atoms
- 88,879
- Mol. weight
- 3741.13 kDa
- Ligands
- ADP, GTP, IHP, MG
- Released
- 13 Mar 2019
Explore 6FF7 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6FF7 contains 714 α-helices and 662 β-strands across 57 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 0: 4 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 230-236 | 7 | |
| β-strand | 238-239 | 2 | 19 |
| β-strand | 242-243 | 2 | 19 |
| α-helix | 247-249 | 3 | |
| β-strand | 252 | 1 | 20 |
| β-strand | 260-261 | 2 | 21 |
| β-strand | 263-264 | 2 | 22 |
| β-strand | 269 | 1 | 22 |
| β-strand | 273-274 | 2 | 21 |
| α-helix | 275-277 | 3 | |
| β-strand | 280-282 | 3 | 20 |
| β-strand | 283-284 | 2 | 23 |
| β-strand | 292-293 | 2 | 23 |
| β-strand | 304-314 | 11 | 20 |
| β-strand | 320-330 | 11 | 20 |
| β-strand | 338-339 | 2 | 22 |
| β-strand | 342-343 | 2 | 22 |
| β-strand | 346 | 1 | 20 |
| β-strand | 350-351 | 2 | 20 |
| α-helix | 356-357 | 2 | |
| β-strand | 358-359 | 2 | 22 |
| β-strand | 368-369 | 2 | 22 |
Chain 1: 3 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-20 | 16 | |
| β-strand | 37-41 | 5 | 1 |
| α-helix | 49-56 | 8 | |
| β-strand | 64-67 | 4 | 1 |
| β-strand | 80-83 | 4 | 1 |
| α-helix | 87-96 | 10 | |
| β-strand | 101 | 1 | 2 |
| β-strand | 106 | 1 | 2 |
| β-strand | 108-111 | 4 | 1 |
Chain 3: 5 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 502-517 | 16 | |
| β-strand | 524 | 1 | 18 |
| α-helix | 531-536 | 6 | |
| α-helix | 546-549 | 4 | |
| α-helix | 571-573 | 3 | |
| α-helix | 594-615 | 22 | |
Chain 7: 3 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-41 | 23 | |
| β-strand | 46-48 | 3 | 42 |
| β-strand | 54-56 | 3 | 42 |
| β-strand | 61-63 | 3 | 42 |
| α-helix | 66-69 | 4 | |
| α-helix | 83-89 | 7 | |
Chain 8: 9 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 462-467 | 6 | |
| α-helix | 485-492 | 8 | |
| α-helix | 499-501 | 3 | |
| α-helix | 526-529 | 4 | |
| α-helix | 533-545 | 13 | |
| α-helix | 549-557 | 9 | |
| α-helix | 569-572 | 4 | |
| α-helix | 573-577 | 5 | |
| α-helix | 579-582 | 4 | |
Chain 9: 29 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-28 | 25 | |
| β-strand | 34 | 1 | 24 |
| α-helix | 35-40 | 6 | |
| β-strand | 42 | 1 | 25 |
| α-helix | 46 | 1 | |
| β-strand | 47 | 1 | 25 |
| α-helix | 48-52 | 5 | |
| α-helix | 53-62 | 10 | |
| α-helix | 65-75 | 11 | |
| α-helix | 85-94 | 10 | |
| α-helix | 98-103 | 6 | |
| α-helix | 119-121 | 3 | |
| α-helix | 126-128 | 3 | |
| α-helix | 135-137 | 3 | |
| α-helix | 143-153 | 11 | |
| α-helix | 160-168 | 9 | |
| α-helix | 169-171 | 3 | |
| α-helix | 180-200 | 21 | |
| α-helix | 206-219 | 14 | |
| α-helix | 221-223 | 3 | |
| β-strand | 227-228 | 2 | 26 |
| β-strand | 232-244 | 13 | 26 |
| β-strand | 246 | 1 | 27 |
| β-strand | 251 | 1 | 27 |
| β-strand | 253 | 1 | 26 |
| α-helix | 256-260 | 5 | |
| α-helix | 266-274 | 9 | |
| α-helix | 276-303 | 28 | |
| α-helix | 306-320 | 15 | |
| α-helix | 324-338 | 15 | |
| α-helix | 394-400 | 7 | |
| β-strand | 406-408 | 3 | 28 |
| β-strand | 414-416 | 3 | 28 |
| α-helix | 419-425 | 7 | |
| α-helix | 429-438 | 10 | |
| α-helix | 452-462 | 11 | |
| α-helix | 469-471 | 3 | |
| α-helix | 478-480 | 3 | |
| α-helix | 489-498 | 10 | |
Chain a: 3 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 27-37 | 11 | |
| β-strand | 42-45 | 4 | 155 |
| β-strand | 51-59 | 9 | 155 |
| β-strand | 65-73 | 9 | 155 |
| β-strand | 79-81 | 3 | 156 |
| β-strand | 85-87 | 3 | 156 |
| α-helix | 92 | 1 | |
| β-strand | 93-101 | 9 | 155 |
| α-helix | 103-105 | 3 | |
| β-strand | 108-110 | 3 | 155 |
Chain A: 90 helices, 69 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 29-44 | 16 | |
| α-helix | 64-73 | 10 | |
| α-helix | 85-90 | 6 | |
| α-helix | 95-103 | 9 | |
| α-helix | 106-108 | 3 | |
| β-strand | 116-121 | 6 | 73 |
| β-strand | 127-128 | 2 | 73 |
| β-strand | 135 | 1 | 74 |
| α-helix | 137-156 | 20 | |
| α-helix | 185-187 | 3 | |
| α-helix | 195-196 | 2 | |
| β-strand | 220 | 1 | 75 |
| β-strand | 227-229 | 3 | 75 |
| α-helix | 232-241 | 10 | |
| α-helix | 260-268 | 9 | |
| α-helix | 291-297 | 7 | |
| α-helix | 310-315 | 6 | |
| β-strand | 361 | 1 | 76 |
| α-helix | 399-405 | 7 | |
| β-strand | 415-417 | 3 | 75 |
| β-strand | 419 | 1 | 74 |
| α-helix | 434-436 | 3 | |
| α-helix | 441-459 | 19 | |
| α-helix | 474-477 | 4 | |
| β-strand | 482-487 | 6 | 73 |
| α-helix | 489-510 | 22 | |
| α-helix | 532-535 | 4 | |
| α-helix | 542-566 | 25 | |
| α-helix | 571-583 | 13 | |
| α-helix | 591-593 | 3 | |
| α-helix | 597-616 | 20 | |
| α-helix | 631-660 | 30 | |
| α-helix | 678-693 | 16 | |
| α-helix | 708-721 | 14 | |
| α-helix | 733-763 | 31 | |
| α-helix | 769-797 | 29 | |
| α-helix | 803-820 | 18 | |
| α-helix | 823-824 | 2 | |
| β-strand | 825 | 1 | 77 |
| α-helix | 826-829 | 4 | |
| α-helix | 836-847 | 12 | |
| α-helix | 859-872 | 14 | |
| α-helix | 874-886 | 13 | |
| β-strand | 894-898 | 5 | 78 |
| β-strand | 907-910 | 4 | 78 |
| α-helix | 911-912 | 2 | |
| α-helix | 913-932 | 20 | |
| β-strand | 940 | 1 | 79 |
| α-helix | 947-948 | 2 | |
| α-helix | 949-953 | 5 | |
| α-helix | 956-960 | 5 | |
| β-strand | 973-980 | 8 | 79 |
| β-strand | 981-982 | 2 | 80 |
| α-helix | 990-996 | 7 | |
| β-strand | 1001 | 1 | 77 |
| α-helix | 1003-1012 | 10 | |
| β-strand | 1017-1018 | 2 | 78 |
| β-strand | 1024 | 1 | 78 |
| α-helix | 1030-1031 | 2 | |
| α-helix | 1037-1052 | 16 | |
| α-helix | 1056-1062 | 7 | |
| α-helix | 1078-1081 | 4 | |
| β-strand | 1085-1091 | 7 | 79 |
| β-strand | 1094-1101 | 8 | 79 |
| α-helix | 1103-1113 | 11 | |
| α-helix | 1140-1141 | 2 | |
| α-helix | 1144-1158 | 15 | |
| β-strand | 1167-1168 | 2 | 80 |
| β-strand | 1174-1178 | 5 | 79 |
| β-strand | 1185-1187 | 3 | 81 |
| β-strand | 1192-1198 | 7 | 81 |
| β-strand | 1215-1217 | 3 | 81 |
| β-strand | 1224-1232 | 9 | 81 |
| α-helix | 1234-1250 | 17 | |
| α-helix | 1256-1271 | 16 | |
| α-helix | 1277-1280 | 4 | |
| α-helix | 1282-1303 | 22 | |
| β-strand | 1337 | 1 | 82 |
| α-helix | 1340-1343 | 4 | |
| β-strand | 1351 | 1 | 82 |
| β-strand | 1354 | 1 | 83 |
| α-helix | 1365-1367 | 3 | |
| α-helix | 1369-1371 | 3 | |
| α-helix | 1375-1398 | 24 | |
| β-strand | 1403 | 1 | 84 |
| α-helix | 1419-1421 | 3 | |
| α-helix | 1427-1430 | 4 | |
| α-helix | 1439-1442 | 4 | |
| α-helix | 1443-1445 | 3 | |
| α-helix | 1458-1461 | 4 | |
| α-helix | 1469-1478 | 10 | |
| β-strand | 1501-1502 | 2 | 85 |
| α-helix | 1521-1524 | 4 | |
| α-helix | 1526-1527 | 2 | |
| α-helix | 1528-1537 | 10 | |
| α-helix | 1539-1541 | 3 | |
| β-strand | 1551-1555 | 5 | 86 |
| α-helix | 1567-1574 | 8 | |
| α-helix | 1581-1595 | 15 | |
| α-helix | 1596-1598 | 3 | |
| β-strand | 1609-1611 | 3 | 87 |
| β-strand | 1629-1631 | 3 | 87 |
| β-strand | 1637-1638 | 2 | 88 |
| β-strand | 1643 | 1 | 89 |
| β-strand | 1656-1657 | 2 | 88 |
| β-strand | 1660-1662 | 3 | 87 |
| β-strand | 1663-1667 | 5 | 90 |
| α-helix | 1676-1688 | 13 | |
| β-strand | 1702-1706 | 5 | 90 |
| β-strand | 1711-1715 | 5 | 90 |
| β-strand | 1716 | 1 | 89 |
| α-helix | 1723-1735 | 13 | |
| α-helix | 1739-1751 | 13 | |
| β-strand | 1754-1755 | 2 | 85 |
| β-strand | 1777-1781 | 5 | 91 |
| α-helix | 1783-1785 | 3 | |
| β-strand | 1788 | 1 | 92 |
| β-strand | 1802 | 1 | 92 |
| β-strand | 1805-1810 | 6 | 91 |
| β-strand | 1816-1822 | 7 | 91 |
| α-helix | 1824-1827 | 4 | |
| α-helix | 1833-1851 | 19 | |
| β-strand | 1860-1863 | 4 | 91 |
| α-helix | 1869-1875 | 7 | |
| β-strand | 1883-1886 | 4 | 91 |
| α-helix | 1895-1897 | 3 | |
| α-helix | 1900-1907 | 8 | |
| β-strand | 1915-1918 | 4 | 91 |
| α-helix | 1929-1945 | 17 | |
| α-helix | 1947-1953 | 7 | |
| β-strand | 1961 | 1 | 18 |
| α-helix | 1973-1995 | 23 | |
| α-helix | 2004-2012 | 9 | |
| α-helix | 2069-2075 | 7 | |
| α-helix | 2080-2086 | 7 | |
| β-strand | 2090 | 1 | 93 |
| β-strand | 2103-2106 | 4 | 93 |
| α-helix | 2108-2115 | 8 | |
| β-strand | 2125-2131 | 7 | 93 |
| β-strand | 2139-2146 | 8 | 93 |
| α-helix | 2147 | 1 | |
| β-strand | 2150 | 1 | 94 |
| β-strand | 2151-2152 | 2 | 95 |
| β-strand | 2157-2158 | 2 | 95 |
| α-helix | 2162-2164 | 3 | |
| β-strand | 2173-2181 | 9 | 93 |
| α-helix | 2190-2202 | 13 | |
| β-strand | 2213-2219 | 7 | 93 |
| β-strand | 2222-2227 | 6 | 93 |
| β-strand | 2228-2229 | 2 | 96 |
| α-helix | 2232-2240 | 9 | |
| α-helix | 2253-2255 | 3 | |
| β-strand | 2257-2258 | 2 | 96 |
| β-strand | 2260-2263 | 4 | 93 |
| β-strand | 2270-2272 | 3 | 93 |
| β-strand | 2273-2274 | 2 | 97 |
| β-strand | 2280 | 1 | 94 |
| α-helix | 2285-2287 | 3 | |
| β-strand | 2296-2297 | 2 | 97 |
49 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| RNA-binding motif protein, X-linked 2 | 1 | protein | 322 | Homo sapiens | Q9Y388 (AlphaFold model) |
| U2 snRNA | 2 | RNA | 188 | Homo sapiens | |
| BUD13 homolog | 3 | protein | 619 | Homo sapiens | Q9BRD0 (AlphaFold model) |
| U5 snRNA | 5 | RNA | 116 | Homo sapiens | |
| U6 snRNA | 6 | RNA | 107 | Homo sapiens | |
| Splicing factor 3A subunit 2 | 7 | protein | 464 | Homo sapiens | Q15428 (AlphaFold model) |
| Splicing factor 3B subunit 2 | 8 | protein | 895 | Homo sapiens | Q13435 (AlphaFold model) |
| Pre-mRNA-processing-splicing factor 8 | A | protein | 2335 | Homo sapiens | Q6P2Q9 |
| 116 kDa U5 small nuclear ribonucleoprotein component | B | protein | 972 | Homo sapiens | Q15029 |
| SNW domain-containing protein 1 | C | protein | 536 | Homo sapiens | Q13573 |
| Pleiotropic regulator 1 | D | protein | 514 | Homo sapiens | O43660 |
| Pre-mRNA-processing factor 17 | E | protein | 579 | Homo sapiens | O60508 |
38 more molecules are not listed.
Sequence of entity 1 (1), FASTA
>6FF7_1 RNA-binding motif protein, X-linked 2 (chains 1)
MNPLTKVKLINELNEREVQLGVADKVSWHSEYKDSAWIFLGGLPYELTEGDIICVFSQYG
EIVNINLVRDKKTGKSKGFCFLCYEDQRSTILAVDNFNGIKIKGRTIRVDHVSNYRAPKD
SEEIDDVTRQLQEKGCGARTPSPSLSESSEDEKPTKKHKKDKKEKKKKKKEKEKADREVQ
AEQPSSSSPRRKTVKEKDDTGPKKHSSKNSERAQKSEPREGQKLPKSRTAYSGGAEDLER
ELKKEKPKHEHKSSSRREAREEKTRIRDRGRSSDAHSSWYNGRSEGRSYRSRSRSRDKSH
RHKRARRSRERESSNPSDRWRH
Sequence of entity 2 (2), FASTA
>6FF7_2 U2 snRNA (chains 2)
AUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUGUUCUUAUCAGUUUAAUAU
CUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAUGGAUUUUUGGAGCAGGGAGAUGGA
AUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUUGCAGUACCUCCAGGAACG
GUGCACCC
Sequence of entity 3 (3), FASTA
>6FF7_3 BUD13 homolog (chains 3)
MAAAPPLSKAEYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTA
ISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFR
HDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRI
RHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISS
PRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSP
HWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPR
HKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAA
HMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQ
RRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQER
EGDPMANFIKKNKAKENKNKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFAR
LASKKAVEELAYKWSVEDM
Sequence of entity 4 (5), FASTA
>6FF7_4 U5 snRNA (chains 5)
AUACUCUGGUUUCUCUUCAGAUCGCAUAAAUCUUUCGCCUUUUACUAAAGAUUUCCGUGG
AGAGGAACAACUCUGAGUCUUAACCCAAUUUUUUGAGCCUUGCCUUGGCAAGGCUA
Sequence of entity 5 (6), FASTA
>6FF7_5 U6 snRNA (chains 6)
GUGCUCGCUUCGGCAGCACAUAUACUAAAAUUGGAACGAUACAGAGAAGAUUAGCAUGGC
CCCUGCGCAAGGAUGACACGCAAAUUCGUGAAGCGUUCCAUAUUUUU
Sequence of entity 6 (7), FASTA
>6FF7_6 Splicing factor 3A subunit 2 (chains 7)
MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCL
TLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVT
KQRDSEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIA
FKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNG
LPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASG
VHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPP
APGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPG
VHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN
Sequence of entity 7 (8), FASTA
>6FF7_7 Splicing factor 3B subunit 2 (chains 8)
MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQ
TGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFP
MAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQ
QKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMG
APVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDA
RSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGS
DSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPK
KKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDV
TAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREAL
QEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETR
LKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPES
CSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSE
EEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSET
PQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAM
TQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF
Sequence of entity 8 (A), FASTA
>6FF7_8 Pre-mRNA-processing-splicing factor 8 (chains A)
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKED
MPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLY
HITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYR
LANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDIN
KIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRR
ALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATK
FFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMR
QIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQF
EGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW
KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLT
RLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLI
LALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMD
LYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGIN
NLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYK
DMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATE
AAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARM
RLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKC
RTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIV
NKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFI
DSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRT
DFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG
LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSY
KMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPAL
YVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTT
KPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQ
IIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLY
DDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVE
VQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLT
ATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKET
GYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP
GQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTP
GSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWN
YNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA
Sequence of entity 9 (B), FASTA
>6FF7_9 116 kDa U5 small nuclear ribonucleoprotein component (chains B)
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLH
EDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTE
RLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLIL
SPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVC
KKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK
MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSEL
PKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV
TFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT
KYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLC
DELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPA
DCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSV
FHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLE
LAKQDVVLNYPM
Sequence of entity 10 (C), FASTA
>6FF7_10 SNW domain-containing protein 1 (chains C)
MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGD
GGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLV
PKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYT
PSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVK
EQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKARE
AVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRR
KERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDS
GFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSG
SDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE
Sequence of entity 11 (D), FASTA
>6FF7_11 Pleiotropic regulator 1 (chains D)
MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPT
SKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSE
SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK
KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL
SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI
DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV
AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT
VNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA
EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF
Sequence of entity 12 (E), FASTA
>6FF7_12 Pre-mRNA-processing factor 17 (chains E)
MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEV
AVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHI
NDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKK
FKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTI
LHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLS
GHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD
TETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGA
VNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQS
MDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTT
KLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 2 |
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 1 |
| IHP | Inositol hexakisphosphate | C6 H18 O24 P6 | 1 |
| MG | Magnesium ion | Mg | 5 |
| ZN | Zinc ion | Zn | 11 |
Primary citation
Structure and Conformational Dynamics of the Human Spliceosomal BactComplex. Haselbach, D., Komarov, I., Agafonov, D.E. et al. Cell (2018) 172:454-464.e11. DOI 10.1016/j.cell.2018.01.010 · PubMed
Other PDB entries of the same protein (UniProt Q9Y388 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7DVQ 2.89 Å, Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex)
- 8I0R 3.0 Å, The cryo-EM structure of human Bact-I complex
- 6FF4 3.4 Å, human Bact spliceosome core structure
- 8I0P 3.4 Å, The cryo-EM structure of human pre-Bact complex
- 7ABH 4.5 Å, Human pre-Bact-2 spliceosome (SF3b/U2 snRNP portion)
- 5Z58 4.9 Å, Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom.
- 5Z56 5.1 Å, cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom.
- 5Z57 6.5 Å, Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom
- 7ABI 8.0 Å, Human pre-Bact-2 spliceosome
Browse structure collections
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