6FF4: Human Bact spliceosome core structure
human Bact spliceosome core structure. Determined by electron microscopy at 3.4 Å resolution. Released 29 Aug 2018.
- Method
- Electron microscopy
- Resolution
- 3.4 Å
- Organism
- Homo sapiens
- Chains
- 28
- Atoms
- 72,392
- Mol. weight
- 2229.57 kDa
- Ligands
- MG, IHP, GTP, ZN
- Released
- 29 Aug 2018
Explore 6FF4 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6FF4 contains 333 α-helices and 306 β-strands across 24 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 1: 4 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-20 | 16 | |
| β-strand | 37-41 | 5 | 1 |
| α-helix | 49-56 | 8 | |
| α-helix | 57-59 | 3 | |
| β-strand | 64-66 | 3 | 1 |
| β-strand | 79-83 | 5 | 1 |
| α-helix | 87-96 | 10 | |
| β-strand | 101 | 1 | 2 |
| β-strand | 106 | 1 | 2 |
| β-strand | 108-111 | 4 | 1 |
Chain 3: 6 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 502-518 | 17 | |
| α-helix | 531-534 | 4 | |
| α-helix | 535-537 | 3 | |
| α-helix | 546-549 | 4 | |
| α-helix | 571-573 | 3 | |
| α-helix | 594-615 | 22 | |
Chain 7: 3 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-41 | 23 | |
| β-strand | 46-48 | 3 | 9 |
| β-strand | 54-56 | 3 | 9 |
| β-strand | 61-63 | 3 | 9 |
| α-helix | 66-69 | 4 | |
| α-helix | 82-89 | 8 | |
Chain 8: 10 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 462-468 | 7 | |
| α-helix | 479-481 | 3 | |
| α-helix | 485-491 | 7 | |
| α-helix | 499-501 | 3 | |
| α-helix | 502-504 | 3 | |
| α-helix | 526-529 | 4 | |
| α-helix | 533-544 | 12 | |
| α-helix | 549-554 | 6 | |
| α-helix | 569-572 | 4 | |
| α-helix | 573-577 | 5 | |
Chain A: 94 helices, 65 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 29-44 | 16 | |
| α-helix | 66-73 | 8 | |
| α-helix | 82-90 | 9 | |
| α-helix | 95-103 | 9 | |
| α-helix | 106-108 | 3 | |
| β-strand | 116-121 | 6 | 10 |
| β-strand | 127-128 | 2 | 10 |
| β-strand | 135 | 1 | 11 |
| α-helix | 137-156 | 20 | |
| α-helix | 185-187 | 3 | |
| α-helix | 193-196 | 4 | |
| α-helix | 203-205 | 3 | |
| β-strand | 220 | 1 | 12 |
| β-strand | 227-229 | 3 | 12 |
| α-helix | 232-241 | 10 | |
| α-helix | 260-268 | 9 | |
| α-helix | 291-297 | 7 | |
| α-helix | 310-315 | 6 | |
| α-helix | 358 | 1 | |
| α-helix | 399-405 | 7 | |
| α-helix | 410-412 | 3 | |
| β-strand | 415-417 | 3 | 12 |
| β-strand | 419 | 1 | 11 |
| α-helix | 434-436 | 3 | |
| α-helix | 441-459 | 19 | |
| α-helix | 474-477 | 4 | |
| β-strand | 482-487 | 6 | 10 |
| α-helix | 489-510 | 22 | |
| β-strand | 516-518 | 3 | 13 |
| β-strand | 524-526 | 3 | 13 |
| α-helix | 542-565 | 24 | |
| α-helix | 571-583 | 13 | |
| α-helix | 596-598 | 3 | |
| α-helix | 599-616 | 18 | |
| α-helix | 631-661 | 31 | |
| α-helix | 678-693 | 16 | |
| α-helix | 708-721 | 14 | |
| α-helix | 733-763 | 31 | |
| α-helix | 769-795 | 27 | |
| α-helix | 803-820 | 18 | |
| α-helix | 823-829 | 7 | |
| α-helix | 836-847 | 12 | |
| α-helix | 859-872 | 14 | |
| α-helix | 874-886 | 13 | |
| β-strand | 894-900 | 7 | 14 |
| β-strand | 905-910 | 6 | 14 |
| α-helix | 913-932 | 20 | |
| β-strand | 940 | 1 | 15 |
| α-helix | 947-948 | 2 | |
| α-helix | 949-953 | 5 | |
| α-helix | 956-960 | 5 | |
| β-strand | 973-980 | 8 | 15 |
| β-strand | 982 | 1 | 16 |
| α-helix | 990-996 | 7 | |
| α-helix | 1003-1011 | 9 | |
| β-strand | 1017-1018 | 2 | 14 |
| β-strand | 1024 | 1 | 14 |
| α-helix | 1030-1031 | 2 | |
| α-helix | 1037-1052 | 16 | |
| α-helix | 1056-1062 | 7 | |
| α-helix | 1078-1081 | 4 | |
| β-strand | 1085-1091 | 7 | 15 |
| β-strand | 1094-1101 | 8 | 15 |
| α-helix | 1103-1113 | 11 | |
| α-helix | 1140-1141 | 2 | |
| α-helix | 1144-1158 | 15 | |
| β-strand | 1167 | 1 | 16 |
| β-strand | 1174-1178 | 5 | 15 |
| β-strand | 1185-1189 | 5 | 17 |
| β-strand | 1192-1198 | 7 | 17 |
| α-helix | 1199-1201 | 3 | |
| β-strand | 1215-1218 | 4 | 17 |
| β-strand | 1223-1230 | 8 | 17 |
| α-helix | 1234-1249 | 16 | |
| α-helix | 1250-1252 | 3 | |
| α-helix | 1256-1271 | 16 | |
| α-helix | 1277-1280 | 4 | |
| α-helix | 1282-1302 | 21 | |
| β-strand | 1337 | 1 | 18 |
| α-helix | 1340-1343 | 4 | |
| β-strand | 1351 | 1 | 18 |
| α-helix | 1353 | 1 | |
| β-strand | 1354 | 1 | 19 |
| α-helix | 1355 | 1 | |
| α-helix | 1365-1367 | 3 | |
| α-helix | 1369-1371 | 3 | |
| α-helix | 1375-1398 | 24 | |
| β-strand | 1403 | 1 | 20 |
| α-helix | 1419-1421 | 3 | |
| α-helix | 1427-1430 | 4 | |
| α-helix | 1441-1445 | 5 | |
| α-helix | 1458-1461 | 4 | |
| α-helix | 1469-1478 | 10 | |
| β-strand | 1502 | 1 | 21 |
| α-helix | 1521-1524 | 4 | |
| α-helix | 1528-1537 | 10 | |
| α-helix | 1539-1542 | 4 | |
| β-strand | 1551-1555 | 5 | 22 |
| α-helix | 1567-1572 | 6 | |
| α-helix | 1581-1595 | 15 | |
| α-helix | 1596-1598 | 3 | |
| β-strand | 1609-1611 | 3 | 23 |
| β-strand | 1629-1631 | 3 | 23 |
| β-strand | 1637-1638 | 2 | 24 |
| β-strand | 1643-1644 | 2 | 23 |
| β-strand | 1656-1657 | 2 | 24 |
| β-strand | 1660-1667 | 8 | 23 |
| α-helix | 1676-1688 | 13 | |
| β-strand | 1701-1706 | 6 | 23 |
| β-strand | 1711-1716 | 6 | 23 |
| α-helix | 1723-1735 | 13 | |
| α-helix | 1739-1749 | 11 | |
| β-strand | 1754 | 1 | 21 |
| β-strand | 1777-1781 | 5 | 25 |
| β-strand | 1787-1788 | 2 | 26 |
| β-strand | 1802-1803 | 2 | 26 |
| β-strand | 1805-1810 | 6 | 25 |
| β-strand | 1816-1822 | 7 | 25 |
| α-helix | 1824-1826 | 3 | |
| α-helix | 1833-1835 | 3 | |
| α-helix | 1837-1851 | 15 | |
| β-strand | 1860-1863 | 4 | 25 |
| α-helix | 1869-1875 | 7 | |
| β-strand | 1883-1886 | 4 | 25 |
| α-helix | 1893-1897 | 5 | |
| α-helix | 1900-1907 | 8 | |
| β-strand | 1915-1918 | 4 | 25 |
| α-helix | 1929-1945 | 17 | |
| α-helix | 1947-1953 | 7 | |
| α-helix | 1973-1994 | 22 | |
| α-helix | 2004-2011 | 8 | |
| α-helix | 2069-2076 | 8 | |
| α-helix | 2077-2079 | 3 | |
| α-helix | 2080-2086 | 7 | |
| β-strand | 2090 | 1 | 27 |
| α-helix | 2092-2094 | 3 | |
| β-strand | 2103-2105 | 3 | 27 |
| α-helix | 2108-2116 | 9 | |
| β-strand | 2125-2131 | 7 | 27 |
| α-helix | 2132-2133 | 2 | |
| β-strand | 2139-2146 | 8 | 27 |
| β-strand | 2150 | 1 | 28 |
| β-strand | 2151-2152 | 2 | 29 |
| β-strand | 2157-2158 | 2 | 29 |
| α-helix | 2162-2164 | 3 | |
| β-strand | 2173-2181 | 9 | 27 |
| α-helix | 2190-2202 | 13 | |
| β-strand | 2213-2219 | 7 | 27 |
| β-strand | 2222-2227 | 6 | 27 |
| β-strand | 2228-2230 | 3 | 30 |
| α-helix | 2232-2240 | 9 | |
| α-helix | 2253-2255 | 3 | |
| β-strand | 2256-2258 | 3 | 30 |
| β-strand | 2260-2262 | 3 | 27 |
| β-strand | 2270-2272 | 3 | 27 |
| β-strand | 2273-2274 | 2 | 31 |
| β-strand | 2280 | 1 | 28 |
| α-helix | 2285-2287 | 3 | |
| β-strand | 2296-2297 | 2 | 31 |
Chain B: 38 helices, 41 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 70-73 | 4 | |
| β-strand | 78-80 | 3 | 32 |
| α-helix | 116-122 | 7 | |
| α-helix | 124-126 | 3 | |
| β-strand | 132-134 | 3 | 33 |
| α-helix | 142-153 | 12 | |
| α-helix | 172-175 | 4 | |
| β-strand | 186-187 | 2 | 33 |
| β-strand | 201-204 | 4 | 33 |
| α-helix | 209-211 | 3 | |
| α-helix | 212-219 | 8 | |
| β-strand | 224 | 1 | 33 |
| β-strand | 227-230 | 4 | 34 |
| β-strand | 234 | 1 | 34 |
| α-helix | 237-248 | 12 | |
| β-strand | 252 | 1 | 33 |
| β-strand | 255-258 | 4 | 34 |
| α-helix | 261 | 1 | |
| α-helix | 262-266 | 5 | |
| α-helix | 271-289 | 19 | |
| β-strand | 307 | 1 | 34 |
| β-strand | 310-311 | 2 | 35 |
| β-strand | 316-317 | 2 | 35 |
| α-helix | 320-328 | 9 | |
| α-helix | 340-342 | 3 | |
| β-strand | 347 | 1 | 36 |
| β-strand | 357 | 1 | 36 |
| α-helix | 369-373 | 5 | |
| α-helix | 374-385 | 12 | |
| α-helix | 392-399 | 8 | |
| α-helix | 405-408 | 4 | |
| α-helix | 412-424 | 13 | |
| α-helix | 428-436 | 9 | |
| α-helix | 445-452 | 8 | |
| α-helix | 461-464 | 4 | |
| β-strand | 476-478 | 3 | 37 |
| β-strand | 480-483 | 4 | 38 |
| α-helix | 484 | 1 | |
| β-strand | 490-495 | 6 | 38 |
| β-strand | 505-507 | 3 | 39 |
| β-strand | 508-509 | 2 | 37 |
| β-strand | 515 | 1 | 40 |
| β-strand | 519 | 1 | 40 |
| β-strand | 525-527 | 3 | 39 |
| β-strand | 531 | 1 | 38 |
| β-strand | 533 | 1 | 41 |
| β-strand | 538 | 1 | 41 |
| β-strand | 549-551 | 3 | 38 |
| β-strand | 563-566 | 4 | 37 |
| α-helix | 577-581 | 5 | |
| β-strand | 588-594 | 7 | 42 |
| α-helix | 600-613 | 14 | |
| β-strand | 618-621 | 4 | 42 |
| β-strand | 627-631 | 5 | 42 |
| α-helix | 634-643 | 10 | |
| α-helix | 644-648 | 5 | |
| β-strand | 653-655 | 3 | 42 |
| β-strand | 659-660 | 2 | 42 |
| β-strand | 663-666 | 4 | 43 |
| β-strand | 686-691 | 6 | 44 |
| α-helix | 694-701 | 8 | |
| α-helix | 711-721 | 11 | |
| α-helix | 726-729 | 4 | |
| α-helix | 737-739 | 3 | |
| β-strand | 745-746 | 2 | 44 |
| α-helix | 765-774 | 10 | |
| β-strand | 784 | 1 | 43 |
| β-strand | 787-793 | 7 | 44 |
| α-helix | 809-821 | 13 | |
| β-strand | 825-838 | 14 | 43 |
| α-helix | 844-851 | 8 | |
| β-strand | 856-861 | 6 | 43 |
| α-helix | 862-863 | 2 | |
| β-strand | 869-876 | 8 | 43 |
| α-helix | 877-879 | 3 | |
| α-helix | 883-890 | 8 | |
| β-strand | 896-906 | 11 | 43 |
| α-helix | 929-937 | 9 | |
| α-helix | 938-942 | 5 | |
Chain C: 11 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 90 | 1 | 45 |
| β-strand | 96 | 1 | 45 |
| α-helix | 99-103 | 5 | |
| α-helix | 111-114 | 4 | |
| α-helix | 116-118 | 3 | |
| α-helix | 121-125 | 5 | |
| α-helix | 129-132 | 4 | |
| α-helix | 134-135 | 2 | |
| α-helix | 137-162 | 26 | |
| β-strand | 176-179 | 4 | 46 |
| β-strand | 196-201 | 6 | 46 |
| α-helix | 225-228 | 4 | |
| α-helix | 233-235 | 3 | |
| α-helix | 241-244 | 4 | |
| α-helix | 283-325 | 43 | |
| β-strand | 407 | 1 | 20 |
Chain D: 4 helices, 29 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 191-193 | 3 | |
| β-strand | 195-200 | 6 | 32 |
| β-strand | 207-212 | 6 | 47 |
| β-strand | 218-223 | 6 | 47 |
| β-strand | 227-232 | 6 | 47 |
| β-strand | 238-243 | 6 | 47 |
| β-strand | 249-254 | 6 | 48 |
| β-strand | 260-265 | 6 | 48 |
| β-strand | 270-274 | 5 | 48 |
| β-strand | 279-280 | 2 | 48 |
| β-strand | 284 | 1 | 48 |
| β-strand | 291-296 | 6 | 49 |
| β-strand | 302-307 | 6 | 49 |
| β-strand | 312-316 | 5 | 49 |
| β-strand | 321-326 | 6 | 49 |
| β-strand | 333-338 | 6 | 50 |
| β-strand | 345-349 | 5 | 50 |
| β-strand | 353-357 | 5 | 50 |
| β-strand | 364-369 | 6 | 50 |
| α-helix | 374-375 | 2 | |
| β-strand | 377-379 | 3 | 51 |
| β-strand | 388-390 | 3 | 51 |
| β-strand | 396-397 | 2 | 52 |
| β-strand | 407-408 | 2 | 52 |
| β-strand | 416-421 | 6 | 53 |
| β-strand | 427-431 | 5 | 53 |
| β-strand | 435-438 | 4 | 53 |
| β-strand | 450-451 | 2 | 53 |
| α-helix | 452-455 | 4 | |
| α-helix | 460-462 | 3 | |
| β-strand | 465-470 | 6 | 32 |
| β-strand | 477-481 | 5 | 32 |
| β-strand | 485-490 | 6 | 32 |
16 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| RNA-binding motif protein, X-linked 2 | 1 | protein | 322 | Homo sapiens | Q9Y388 (AlphaFold model) |
| U2 snRNA | 2 | RNA | 188 | Homo sapiens | |
| BUD13 homolog | 3 | protein | 619 | Homo sapiens | Q9BRD0 (AlphaFold model) |
| U5 snRNA | 5 | RNA | 116 | Homo sapiens | |
| U6 snRNA | 6 | RNA | 107 | Homo sapiens | |
| Splicing factor 3A subunit 2 | 7 | protein | 464 | Homo sapiens | Q15428 (AlphaFold model) |
| Splicing factor 3B subunit 2 | 8 | protein | 895 | Homo sapiens | Q13435 (AlphaFold model) |
| Pre-mRNA-processing-splicing factor 8 | A | protein | 2335 | Homo sapiens | Q6P2Q9 |
| 116 kDa U5 small nuclear ribonucleoprotein component | B | protein | 972 | Homo sapiens | Q15029 |
| SNW domain-containing protein 1 | C | protein | 536 | Homo sapiens | Q13573 |
| Pleiotropic regulator 1 | D | protein | 514 | Homo sapiens | O43660 |
| Pre-mRNA-processing factor 17 | E | protein | 579 | Homo sapiens | O60508 |
16 more molecules are not listed.
Sequence of entity 1 (1), FASTA
>6FF4_1 RNA-binding motif protein, X-linked 2 (chains 1)
MNPLTKVKLINELNEREVQLGVADKVSWHSEYKDSAWIFLGGLPYELTEGDIICVFSQYG
EIVNINLVRDKKTGKSKGFCFLCYEDQRSTILAVDNFNGIKIKGRTIRVDHVSNYRAPKD
SEEIDDVTRQLQEKGCGARTPSPSLSESSEDEKPTKKHKKDKKEKKKKKKEKEKADREVQ
AEQPSSSSPRRKTVKEKDDTGPKKHSSKNSERAQKSEPREGQKLPKSRTAYSGGAEDLER
ELKKEKPKHEHKSSSRREAREEKTRIRDRGRSSDAHSSWYNGRSEGRSYRSRSRSRDKSH
RHKRARRSRERESSNPSDRWRH
Sequence of entity 2 (2), FASTA
>6FF4_2 U2 snRNA (chains 2)
AUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUGUUCUUAUCAGUUUAAUAU
CUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAUGGAUUUUUGGAGCAGGGAGAUGGA
AUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUUGCAGUACCUCCAGGAACG
GUGCACCC
Sequence of entity 3 (3), FASTA
>6FF4_3 BUD13 homolog (chains 3)
MAAAPPLSKAEYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTA
ISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFR
HDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRI
RHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISS
PRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSP
HWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPR
HKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAA
HMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQ
RRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQER
EGDPMANFIKKNKAKENKNKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFAR
LASKKAVEELAYKWSVEDM
Sequence of entity 4 (5), FASTA
>6FF4_4 U5 snRNA (chains 5)
AUACUCUGGUUUCUCUUCAGAUCGCAUAAAUCUUUCGCCUUUUACUAAAGAUUUCCGUGG
AGAGGAACAACUCUGAGUCUUAACCCAAUUUUUUGAGCCUUGCCUUGGCAAGGCUA
Sequence of entity 5 (6), FASTA
>6FF4_5 U6 snRNA (chains 6)
GUGCUCGCUUCGGCAGCACAUAUACUAAAAUUGGAACGAUACAGAGAAGAUUAGCAUGGC
CCCUGCGCAAGGAUGACACGCAAAUUCGUGAAGCGUUCCAUAUUUUU
Sequence of entity 6 (7), FASTA
>6FF4_6 Splicing factor 3A subunit 2 (chains 7)
MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCL
TLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVT
KQRDSEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIA
FKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNG
LPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASG
VHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPP
APGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPG
VHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN
Sequence of entity 7 (8), FASTA
>6FF4_7 Splicing factor 3B subunit 2 (chains 8)
MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQ
TGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFP
MAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQ
QKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMG
APVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDA
RSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGS
DSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPK
KKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDV
TAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREAL
QEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETR
LKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPES
CSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSE
EEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSET
PQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAM
TQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF
Sequence of entity 8 (A), FASTA
>6FF4_8 Pre-mRNA-processing-splicing factor 8 (chains A)
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKED
MPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLY
HITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYR
LANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDIN
KIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRR
ALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATK
FFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMR
QIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQF
EGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW
KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLT
RLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLI
LALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMD
LYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGIN
NLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYK
DMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATE
AAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARM
RLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKC
RTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIV
NKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFI
DSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRT
DFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG
LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSY
KMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPAL
YVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTT
KPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQ
IIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLY
DDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVE
VQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLT
ATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKET
GYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP
GQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTP
GSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWN
YNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA
Sequence of entity 9 (B), FASTA
>6FF4_9 116 kDa U5 small nuclear ribonucleoprotein component (chains B)
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLH
EDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTE
RLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLIL
SPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVC
KKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK
MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSEL
PKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV
TFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT
KYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLC
DELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPA
DCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSV
FHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLE
LAKQDVVLNYPM
Sequence of entity 10 (C), FASTA
>6FF4_10 SNW domain-containing protein 1 (chains C)
MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGD
GGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLV
PKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYT
PSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVK
EQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKARE
AVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRR
KERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDS
GFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSG
SDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE
Sequence of entity 11 (D), FASTA
>6FF4_11 Pleiotropic regulator 1 (chains D)
MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPT
SKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSE
SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK
KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL
SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI
DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV
AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT
VNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA
EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF
Sequence of entity 12 (E), FASTA
>6FF4_12 Pre-mRNA-processing factor 17 (chains E)
MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEV
AVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHI
NDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKK
FKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTI
LHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLS
GHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD
TETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGA
VNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQS
MDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTT
KLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 4 |
| IHP | Inositol hexakisphosphate | C6 H18 O24 P6 | 1 |
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 1 |
| ZN | Zinc ion | Zn | 10 |
Primary citation
Structure and Conformational Dynamics of the Human Spliceosomal BactComplex. Haselbach, D., Komarov, I., Agafonov, D.E. et al. Cell (2018) 172:454-464.e11. DOI 10.1016/j.cell.2018.01.010 · PubMed
Other PDB entries of the same protein (UniProt Q9Y388 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7DVQ 2.89 Å, Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex)
- 8I0R 3.0 Å, The cryo-EM structure of human Bact-I complex
- 8I0P 3.4 Å, The cryo-EM structure of human pre-Bact complex
- 6FF7 4.5 Å, human Bact spliceosome core structure
- 7ABH 4.5 Å, Human pre-Bact-2 spliceosome (SF3b/U2 snRNP portion)
- 5Z58 4.9 Å, Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom.
- 5Z56 5.1 Å, cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom.
- 5Z57 6.5 Å, Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom
- 7ABI 8.0 Å, Human pre-Bact-2 spliceosome
Browse structure collections
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