Centromere protein U (CENPU) is a 418-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q71F23.
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The mean pLDDT of this model is 65.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 29% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 40% |
What pLDDT means and how to read it
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression
Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts with MLF1. Interacts with PLK1
Cytoplasm, Nucleus, Chromosome, centromere, kinetochore
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9FJG | X-ray | 2.0 Å | C=58-114 |
| 9FJJ | X-ray | 2.0 Å | U=39-114 |
| 9FJI | X-ray | 2.1 Å | C=58-114 |
| 9FJH | X-ray | 2.15 Å | C=58-114 |
| 7R5S | EM | 2.83 Å | U=1-418 |
| 7PKN | EM | 3.2 Å | U=1-418 |
| 7XHO | EM | 3.29 Å | U=1-418 |
| 8K4D | X-ray | 3.52 Å | C=41-49 |
| 7PB8 | X-ray | 3.68 Å | U=1-418 |
| 7XHN | EM | 3.71 Å | U=1-418 |
| 7R5V | EM | 4.55 Å | U=1-418 |
| 7QOO | EM | 4.6 Å | U=1-418 |
| 7YYH | EM | 8.9 Å | U=1-418 |
| 7YWX | EM | 12.0 Å | U=1-418 |
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