Tubulin alpha-1A chain (TUBA1A) is a 451-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q71U36.
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The mean pLDDT of this model is 91.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 80% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13…
Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, flagellum axoneme
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9WD9 | EM | 2.26 Å | a=1-451 |
| 6J8F | X-ray | 2.28 Å | C=444-451 |
| 9WD7 | EM | 2.34 Å | a=1-451 |
| 9WDA | EM | 2.35 Å | a=1-451 |
| 9WDB | EM | 2.39 Å | a=1-451 |
| 22AK | EM | 2.41 Å | A=1-451 |
| 22AJ | EM | 2.48 Å | A=1-451 |
| 9OX7 | EM | 2.69 Å | A/C/G/H=1-451 |
| 8SH7 | EM | 2.8 Å | A=1-451 |
| 6WSL | EM | 3.1 Å | A/E=1-451 |
| 7UNG | EM | 3.6 Å | AA/AC/AE/AG/AI/AK/AM/BA/BC/BE/BG/BI/BK/BM/CA/CC/CE/CG/CI/CK/CM/DA/DC/DE/DG/DI/DK/DM/EC/EE=1-451 |
| 5JCO | EM | 4.0 Å | A/B/E/F/G/H=1-437 |
| 8J07 | EM | 4.1 Å | AC/AE/AG/AI/AK/AM/AO/AQ/AS/AU/AW/AY/AZ/BA/BC/BE/BG/BI/BK/BM/BO/BQ/BS/BU/BW/BY/CC/CE/CG/CI=1-451 |
| 7UN1 | EM | 6.0 Å | AC/AE/BC/BE/BG/CC/CE/CG/DC/DE/DG/EC/EE/EG/FC/FE/FG/GC/GE/GG/HC/HE/HG/IC/IE/IG/JC/JE/JG/KC=1-451 |
| 7C1M | NMR | B=440-451 |
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