Hemagglutinin glycoprotein (H) is a 617-residue protein from Measles virus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: Q786F2.
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The mean pLDDT of this model is 74.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Attaches the virus to the human SLAMF1/CD150 receptor for entry into host dendritic cells, macrophages, activated memory T cells and naive or memory B cells, thereby explaining the long immunosuppression that follows infection (By similarity). In the respiratory airways, binds to the NECTIN4 receptor for entry into the host cell (PubMed:22048310). During viral entry or virus-mediated fusion between infected cells and neighboring susceptible cells, the head domain of the H protein initially binds to its receptor and then the stalk region of the H protein transmits the fusion-triggering signal to the F protein (PubMed:23027974). Unilateral receptor binding to only one of the covalently…
Homodimer; disulfide-linked (PubMed:23027974, PubMed:23202587, PubMed:24648460). Further forms homotetramer (dimer of dimers) (PubMed:23027974, PubMed:24648460). Interacts (via C-terminus) with human NECTIN4 (via N-terminus); this interaction allows attachment to the respiratory epithelium and viral entry (PubMed:22048310, PubMed:23202587). Interacts (via C-terminus) with human SLAMF1/CD150 (via…
Virion membrane, Host cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4GJT | X-ray | 3.1 Å | A=156-617 |
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