Actin-histidine N-methyltransferase (SETD3) is a 594-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q86TU7.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 86.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 80% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018)
Interacts with MYOD1
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6MBK | X-ray | 1.69 Å | A/B=21-503, A/B=1-594 |
| 6OX0 | X-ray | 1.75 Å | A/B=1-594 |
| 6WK2 | X-ray | 1.76 Å | A/D=1-594 |
| 6MBJ | X-ray | 1.78 Å | A/B=21-500, A/B=1-594 |
| 6OX3 | X-ray | 1.78 Å | A/B=1-594 |
| 7W28 | X-ray | 1.79 Å | A=1-498 |
| 6WK1 | X-ray | 1.89 Å | A/B=1-594 |
| 6ICT | X-ray | 1.95 Å | A/B/C/D=1-503 |
| 6OX1 | X-ray | 1.95 Å | A/B=1-594 |
| 6V63 | X-ray | 2.02 Å | A/B=1-594 |
| 3SMT | X-ray | 2.04 Å | A=2-498 |
| 6OX2 | X-ray | 2.09 Å | A/B=1-594 |
| 6OX5 | X-ray | 2.1 Å | A=1-594 |
| 6ICV | X-ray | 2.15 Å | A/B=1-503 |
| 6MBL | X-ray | 2.2 Å | A=21-500, A=1-594 |
| 6OX4 | X-ray | 2.29 Å | A/B=1-594 |
| 6V62 | X-ray | 2.36 Å | A=1-594 |
| 6JAT | X-ray | 2.71 Å | A/C=1-498 |
| 7W29 | X-ray | 2.9 Å | A=1-498 |
| 8X8Q | EM | 3.14 Å | B=1-594 |
Showing 20 of 22 experimental structures (best resolution first).
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