Tax1-binding protein 1 (TAX1BP1) is a 789-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q86VP1.
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The mean pLDDT of this model is 75.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination…
Homooligomer. Interacts with TNFAIP3. Interacts with STARD13. Interacts with MYO6 (PubMed:31371777). Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and TAX1BP1 (PubMed:31371777). Interacts with MAVS; this interaction induces MAVS polyubiquitination (PubMed:27736772). Interacts with TNIP1 (PubMed:21885437). Interacts with TRAF6; this…
Cytoplasm, Mitochondrion, Preautophagosomal structure, Cytoplasmic vesicle, autophagosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5YT6 | X-ray | 1.5 Å | B/D/F/H=754-787 |
| 8W6A | X-ray | 1.53 Å | C/E/F/H=123-151 |
| 4NLH | X-ray | 1.9 Å | A/B=15-147 |
| 4Z4M | X-ray | 2.15 Å | A/B=755-781 |
| 5Z7G | X-ray | 2.3 Å | A/B=1-121 |
| 8W6B | X-ray | 2.39 Å | A/B/E/F=1-121 |
| 4BMJ | X-ray | 2.75 Å | A/B/C/D/E/F/G/H/I/J/K=725-789 |
| 4Z4K | X-ray | 2.8 Å | A/B=725-781 |
| 2M7Q | NMR | A=725-789 | |
| 5AAS | NMR | A=722-784 |
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