DNA dC->dU-editing enzyme APOBEC-3F (APOBEC3F) is a 373-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8IUX4.
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The mean pLDDT of this model is 89.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 63% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms (PubMed:15141007, PubMed:17121840, PubMed:20062055, PubMed:22915799, PubMed:34774569). Exhibits antiviral activity against viruse such as HIV-1 or HIV-2 (PubMed:15141007, PubMed:15152192, PubMed:17121840, PubMed:20219927, PubMed:21835787, PubMed:22807680, PubMed:23001005, PubMed:23097438, PubMed:23152537, PubMed:34774569). After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense…
Homodimer (PubMed:27139641). Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599, PubMed:31792451). Interacts with AGO1, AGO2 and AGO3 (PubMed:22915799)
Cytoplasm, Cytoplasm, P-body
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5HX4 | X-ray | 1.92 Å | A/B=185-373 |
| 5ZVB | X-ray | 2.0 Å | A/B=220-373 |
| 5ZVA | X-ray | 2.3 Å | A/B=220-373 |
| 5HX5 | X-ray | 2.33 Å | A/B=185-373 |
| 3WUS | X-ray | 2.54 Å | A/B=187-373 |
| 8VUD | X-ray | 2.6 Å | A/B=1-190 |
| 4IOU | X-ray | 2.75 Å | A/B/C/D=185-373 |
| 4J4J | X-ray | 3.1 Å | A/B=218-373 |
| 5W2M | X-ray | 3.7 Å | A/B/C/D/J/K/L/M=190-373 |
| 6NIL | EM | 3.9 Å | A/D/G/J=185-373 |
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