Microcephalin (MCPH1) is a 835-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8NEM0.
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The mean pLDDT of this model is 59.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 53% |
What pLDDT means and how to read it
Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex
Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3PA6 | X-ray | 1.5 Å | A/B/C=1-105 |
| 3U3Z | X-ray | 1.5 Å | A=640-835 |
| 2WT8 | X-ray | 1.6 Å | A/B/C/D=1-95 |
| 3KTF | X-ray | 1.6 Å | A/B/C=1-101 |
| 3SHT | X-ray | 1.95 Å | A/B/C=639-835 |
| 3SHV | X-ray | 2.1 Å | A/B=639-835 |
| 7C5D | X-ray | 2.15 Å | C/D=322-342 |
| 3T1N | X-ray | 2.6 Å | A/B=640-835 |
| 3SZM | X-ray | 2.63 Å | A/B/C/D/E/F/G/H=640-835 |
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