3PA6: N-terminal BRCT domain of human microcephalin

Structure of the N-terminal BRCT domain of human microcephalin (MCPH1). Determined by X-ray diffraction at 1.5 Å resolution. Released 8 Dec 2010.

Method: X-ray diffraction
Resolution: 1.5 Å
Organism: Homo sapiens
Chains: 3
Atoms: 2,642
Mol. weight: 36.3 kDa
Released: 8 Dec 2010

Explore 3PA6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3PA6 contains 12 α-helices and 21 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B and C: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	10-15	6	1
β-strand	16	1	2
β-strand	23	1	2
α-helix	25-34	10
β-strand	38-39	2	1
β-strand	49-53	5	1
α-helix	57-66	10
β-strand	69-71	3	1
α-helix	73-82	10
α-helix	88-90	3
β-strand	92	1	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Microcephalin	A, B, C	protein	107	Homo sapiens	Q8NEM0 (AlphaFold model)

Sequence of entity 1 (A, B, C), FASTA

>3PA6_1 Microcephalin (chains A, B, C)
GHMAAPILKDVVAYVEVWSSNGTENYSKTFTTQLVDMGAKVSKTFNKQVTHVIFKDGYQS
TWDKAQKRGVKLVSVLWVEKCRTAGAHIDESLFPAANMNEHLSSLIK

Primary citation

Structure of the N-terminal BRCT domain of human microcephalin (MCPH1). Singh, N., Heroux, A., Thompson, J.R. et al. To be published.

Other PDB entries of the same protein (UniProt Q8NEM0 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3U3Z 1.5 Å, Structure of human microcephalin (MCPH1) tandem BRCT domains in complex with an H2A.X…
2WT8 1.6 Å, Structure of the N-terminal BRCT domain of human microcephalin (Mcph1)
3KTF 1.6 Å, Structure of the N-terminal BRCT domain of human microcephalin (MCPH1).
3SHT 1.95 Å, Crystal structure of human MCPH1 tandem BRCT domains
3SHV 2.1 Å, Crystal structure of human MCPH1 tandem BRCT domains-gamma H2AX complex
7C5D 2.15 Å, Crystal structure of TRF2 TRFH domain in complex with a MCPH1 peptide
3T1N 2.6 Å, Structure of human MICROCEPHALIN (MCPH1) TANDEM BRCT domains in complex with a CDC27…
3SZM 2.63 Å, Structure of human microcephalin (MCPH1) tandem brct domains in complex with a…

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