F-box/WD repeat-containing protein 7 (FBXW7) is a 707-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q969H0.
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The mean pLDDT of this model is 77.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 61% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17434132, PubMed:22748924, PubMed:26976582, PubMed:28727686, PubMed:34741373, PubMed:35395208). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination (PubMed:17434132, PubMed:22748924, PubMed:26774286, PubMed:26976582, PubMed:28727686, PubMed:34741373). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1,…
Homodimer; homodimerization plays a role in substrate binding and/or ubiquitination and degradation (PubMed:17434132, PubMed:22608923, PubMed:28007894). Component of the SCF(FBXW7) complex consisting of CUL1, RBX1, SKP1 and FBXW7 (PubMed:11565034, PubMed:15103331, PubMed:22748924, PubMed:26774286, PubMed:26976582, PubMed:28007894, PubMed:28727686, PubMed:34741373). Interacts (via F-box domain)…
Nucleus, nucleoplasm, Chromosome, Cytoplasm, Nucleus, nucleolus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2OVR | X-ray | 2.5 Å | B=263-707 |
| 5IBK | X-ray | 2.5 Å | B/E=263-323 |
| 7T1Y | X-ray | 2.55 Å | B=263-707 |
| 2OVQ | X-ray | 2.6 Å | B=263-707 |
| 5V4B | X-ray | 2.6 Å | B=263-706 |
| 7T1Z | X-ray | 2.77 Å | B=263-707 |
| 2OVP | X-ray | 2.9 Å | B=263-707 |
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