Splicing factor 45 (RBM17) is a 401-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96I25.
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The mean pLDDT of this model is 68.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 29% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia
Binds SXL. Associates with the spliceosome. Interacts with SF3B1, SF1 and U2AF2
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6HIP | X-ray | 1.2 Å | A/B=301-401 |
| 2PE8 | X-ray | 2.0 Å | A=301-401 |
| 2PEH | X-ray | 2.11 Å | A/B=301-401 |
| 5LSO | X-ray | 2.22 Å | A/B=301-400 |
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