Chromosome alignment-maintaining phosphoprotein 1 (CHAMP1) is a 812-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96JM3.
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The mean pLDDT of this model is 47.6 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 1% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 75% |
What pLDDT means and how to read it
Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore
Interacts with MAD2L2. Interacts with POGZ, CBX1, CBX3 and CBX5
Nucleus, Chromosome, Chromosome, centromere, kinetochore, Cytoplasm, cytoskeleton, spindle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6EKJ | X-ray | 1.6 Å | B=328-355 |
| 6EKL | X-ray | 1.6 Å | B=328-355 |
| 5XPT | X-ray | 2.1 Å | B=325-344 |
| 5XPU | X-ray | 2.3 Å | B=325-344 |
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