Mas-related G-protein coupled receptor member X2 (MRGPRX2) is a 330-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96LB1.
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The mean pLDDT of this model is 81.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Mast cell-specific G protein-coupled receptor for basic secretagogues, which regulates mast cell degranulation and itch-related hypersensitivity reactions (PubMed:22069323, PubMed:25517090, PubMed:28288109, PubMed:34789874, PubMed:34789875). A secretagogue is an agent that promotes the secretion of hormones, neurohormones, chemical neurotransmitters or other compounds synthesized and secreted by cells (PubMed:25517090). Basic secretagogues comprise a set of cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Ligand binding causes a conformation change that triggers signaling via guanine…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7S8L | EM | 2.45 Å | R=2-330 |
| 7S8M | EM | 2.54 Å | R=2-330 |
| 7S8O | EM | 2.58 Å | R=2-330 |
| 7VV5 | EM | 2.76 Å | R=1-330 |
| 7VUY | EM | 2.84 Å | R=1-330 |
| 7VUZ | EM | 2.89 Å | R=1-330 |
| 7S8N | EM | 2.9 Å | R=2-330 |
| 7VDH | EM | 2.9 Å | R=1-330 |
| 7VV3 | EM | 2.97 Å | R=1-330 |
| 7VV4 | EM | 2.97 Å | R=1-330 |
| 7VDM | EM | 2.98 Å | R=1-330 |
| 7VDL | EM | 3.22 Å | R=1-330 |
| 7VV6 | EM | 3.3 Å | R=1-330 |
| 7VV0 | EM | 3.5 Å | R=1-330 |
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