Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1) is a 1491-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96QZ7.
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The mean pLDDT of this model is 59.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 22% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 50% |
What pLDDT means and how to read it
Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity)
Part of a complex composed of AMOTL2, MAGI1 and CDH5, within the complex AMOTL2 acts as a scaffold protein for the interaction of MAGI1 with CDH5 (By similarity). The complex is required for coupling actin fibers to cell junctions in endothelial cells (By similarity). Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4 (PubMed:12042308). Interacts with…
Cell junction, tight junction, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3BPU | X-ray | 1.6 Å | A=640-721 |
| 2Q9V | X-ray | 2.0 Å | A=839-922 |
| 2R4H | X-ray | 2.05 Å | A/B/C=1149-1233 |
| 5N7D | X-ray | 2.3 Å | A/B=455-558 |
| 5N7F | X-ray | 2.3 Å | A/B=454-558 |
| 6TWX | X-ray | 2.3 Å | A/B=455-558 |
| 6TWY | X-ray | 2.3 Å | A/B=458-558 |
| 1WBP | X-ray | 2.4 Å | B=1382-1390 |
| 6TWU | X-ray | 2.4 Å | A/B=458-558 |
| 7P71 | X-ray | 2.6 Å | A/B=455-558 |
| 5N7G | X-ray | 2.95 Å | A/B=455-558 |
| 2KPK | NMR | A=455-580 | |
| 2KPL | NMR | A=455-580 | |
| 2YSD | NMR | A=295-338 | |
| 2YSE | NMR | A=355-401 | |
| 2ZAJ | NMR | A=355-390 |
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