BRCA1-associated RING domain protein 1 (BARD1) is a 777-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q99728.
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The mean pLDDT of this model is 64.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 41% |
What pLDDT means and how to read it
E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage
Homo- and heterodimer. Heterodimer (RING-type zinc finger) with BRCA1. Heterodimer (via ANK repeats and BRCT domains) with CSTF1/CSTF-50. Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts with UBXN1
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6M14 | X-ray | 1.88 Å | A/B=568-777 |
| 2NTE | X-ray | 1.9 Å | A/B=568-777 |
| 3C5R | X-ray | 2.0 Å | A/B=425-555 |
| 2R1Z | X-ray | 2.1 Å | A/B=569-777 |
| 3FA2 | X-ray | 2.2 Å | A/B=566-777 |
| 7LYC | EM | 2.94 Å | N=415-777 |
| 7E8I | EM | 3.1 Å | K=425-777 |
| 7LYB | EM | 3.28 Å | N=26-122 |
| 8GRQ | EM | 3.87 Å | M=26-117 |
| 7JZV | EM | 3.9 Å | B=26-140 |
| 1JM7 | NMR | B=26-140 |
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