Ras-related protein Rab-27B (Rab27b) is a 218-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q99P58.
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The mean pLDDT of this model is 85.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 63% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB27B regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to…
Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A. Interacts (GDP-bound form preferentially) with DENND10 (By similarity)
Membrane, Late endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2IEZ | X-ray | 2.8 Å | A/B/H/I=1-218 |
| 2IF0 | X-ray | 2.8 Å | A/B=1-198 |
| 2ZET | X-ray | 3.0 Å | A/B=1-201 |
| 2IEY | X-ray | 3.18 Å | A/B=1-193 |
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