Crooked neck-like protein 1 (CRNKL1) is a 848-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BZJ0.
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The mean pLDDT of this model is 74.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 39% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
Involved in pre-mRNA splicing process (PubMed:11991638, PubMed:12084575, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)
Identified in the spliceosome C complex (PubMed:11991638, PubMed:28076346, PubMed:28502770). Present in a spliceosome complex assembled in vitro containing CRNKL1, HPRP8BP and SNRPB2 (PubMed:12084575). Component of the minor spliceosome, which splices U12-type introns (PubMed:33509932). Isoform 2 seems to be predominant in the spliceosome complex (PubMed:12084575). Interacts with PPIL2 (via the…
Nucleus, Nucleus speckle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8C6J | EM | 2.8 Å | S=162-848 |
| 6ID1 | EM | 2.86 Å | J=1-848 |
| 7DVQ | EM | 2.89 Å | J=1-848 |
| 6ID0 | EM | 2.9 Å | J=1-848 |
| 6ICZ | EM | 3.0 Å | J=1-848 |
| 8I0R | EM | 3.0 Å | J=1-848 |
| 8I0T | EM | 3.0 Å | J=1-848 |
| 8I0V | EM | 3.0 Å | J=1-848 |
| 7QTT | EM | 3.1 Å | X=1-848 |
| 6QDV | EM | 3.3 Å | S=1-848 |
| 8I0U | EM | 3.3 Å | J=1-848 |
| 9FMD | EM | 3.3 Å | J=1-848 |
| 6ZYM | EM | 3.4 Å | O=1-848 |
| 8I0P | EM | 3.4 Å | J=1-848 |
| 8I0W | EM | 3.4 Å | J=1-848 |
| 8RO2 | EM | 3.5 Å | J=1-848 |
| 5XJC | EM | 3.6 Å | J=1-848 |
| 7W59 | EM | 3.6 Å | J=1-848 |
| 7W5A | EM | 3.6 Å | J=1-848 |
| 5YZG | EM | 4.1 Å | J=1-848 |
Showing 20 of 31 experimental structures (best resolution first).
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