Histone acetyltransferase KAT8 (KAT8) is a 458-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H7Z6.
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The mean pLDDT of this model is 81.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:31794431, PubMed:33837287). Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:33657400, PubMed:33837287). H4K16ac constitutes the only…
Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1 (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:30224647, PubMed:33657400, PubMed:33837287). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:16543150,…
Nucleus, Chromosome, Mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9OOA | X-ray | 1.39 Å | A=174-449 |
| 2PQ8 | X-ray | 1.45 Å | A=174-449 |
| 9OOF | X-ray | 1.68 Å | A=174-449 |
| 6OIN | X-ray | 1.7 Å | A=176-448 |
| 6OIO | X-ray | 1.7 Å | A=176-448 |
| 6OIQ | X-ray | 1.75 Å | A=176-448 |
| 6OWI | X-ray | 1.75 Å | A=176-448 |
| 5WCI | X-ray | 1.78 Å | A=174-449 |
| 6OIP | X-ray | 1.8 Å | A=176-448 |
| 8W13 | X-ray | 1.81 Å | A=174-449 |
| 9OOJ | X-ray | 1.82 Å | A=174-449 |
| 9OOB | X-ray | 1.83 Å | A=174-449 |
| 6BA2 | X-ray | 1.85 Å | A=174-449 |
| 6PDG | X-ray | 1.92 Å | A=177-448 |
| 2GIV | X-ray | 1.94 Å | A=174-449 |
| 6BA4 | X-ray | 1.95 Å | A=174-449 |
| 6PDC | X-ray | 1.96 Å | A=177-448 |
| 6OWH | X-ray | 2.0 Å | A=176-448 |
| 6OIR | X-ray | 2.03 Å | A=176-448 |
| 4DNC | X-ray | 2.05 Å | A/B=170-458 |
Showing 20 of 43 experimental structures (best resolution first).
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