Adhesion G protein-coupled receptor L3 (ADGRL3) is a 1447-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9HAR2.
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The mean pLDDT of this model is 69.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
Orphan adhesion G protein-coupled receptor (aGPCR), which mediates synapse specificity (PubMed:35418682). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35418682). ADGRL3 is coupled with different classes of G alpha proteins, such as G(12)/G(13), G(s), G(i) or G(q), depending on the context (PubMed:35418682). Coupling to G(12)/G(13) G proteins, which mediates the activation Rho small GTPases is the most efficient (PubMed:35418682). Following G protein-coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of…
Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked (By similarity). Interacts (via olfactomedin-like domain) with FLRT1 (via extracellular domain) (By similarity). Interacts (via olfactomedin-like domain) with FLRT2 (via extracellular domain)…
Cell membrane, Postsynaptic cell membrane, Cell projection, axon, Cell junction
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8DJG | X-ray | 2.65 Å | E/F=24-126 |
| 7SF7 | EM | 2.9 Å | A=842-1138 |
| 6VHH | EM | 2.97 Å | B=21-866 |
| 8JMT | EM | 3.36 Å | A=500-1038, A=1041-1046, A=1048-1119 |
| 5CMN | X-ray | 3.6 Å | E/F/G/H=132-392 |
| 8VTI | EM | 3.9 Å | A=490-841, B=842-1138 |
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