Neuroglobin (NGB) is a 151-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NPG2.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 95.2 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 93% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide (PubMed:11473128, PubMed:12962627, PubMed:24699645). Could help transport oxygen and increase its availability to the metabolically active neuronal tissues, though its low quantity in tissues as well as its high affinity for dioxygen, which may limit its oxygen-releasing ability, argue against it (PubMed:11473128, PubMed:12860983, PubMed:12962627, PubMed:24699645). The ferrous/deoxygenated form exhibits a nitrite reductase activity and it could produce nitric oxide which in turn inhibits cellular respiration in response to hypoxia (PubMed:21296891). In its…
Monomer (PubMed:11029004). Homodimer and homotetramer; disulfide-linked. Mainly monomeric but also detected as part of homodimers and homotetramers (By similarity). Interacts with 14-3-3 proteins; regulates the phosphorylation of NGB (PubMed:21965683). Could interact (ferrous form) with G-alpha(i) proteins (GTP-bound form) (PubMed:12860983)
Cytoplasm, cytosol, Mitochondrion matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7VQG | X-ray | 1.35 Å | A=2-149 |
| 8WUB | X-ray | 1.5 Å | A/B/C=1-151 |
| 4MPM | X-ray | 1.74 Å | A/B=1-151 |
| 1OJ6 | X-ray | 1.95 Å | A/B/C/D=1-151 |
| 8GRZ | X-ray | 2.0 Å | A=1-151 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.