Protection of telomeres protein 1 (POT1) is a 634-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NUX5.
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The mean pLDDT of this model is 87.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 69% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by…
Homodimer or homooligomer (PubMed:17237768). Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1 (PubMed:15316005, PubMed:15383534). Binds single-stranded telomeric DNA as a monomer (PubMed:15558049). Associated component of the telomerase holoenzyme complex (PubMed:19179534). Found in a complex with TERF1, TINF2 and TNKS1 (PubMed:12768206).…
Nucleus, Chromosome, telomere
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1XJV | X-ray | 1.73 Å | A=6-299 |
| 3KJO | X-ray | 1.8 Å | A=1-299 |
| 3KJP | X-ray | 1.8 Å | A=1-299 |
| 5H65 | X-ray | 2.1 Å | A=341-634 |
| 5UN7 | X-ray | 2.1 Å | A=330-634 |
| 8SH0 | X-ray | 2.16 Å | A=1-299 |
| 7S1O | X-ray | 2.55 Å | A/B=325-634 |
| 7S1U | X-ray | 2.55 Å | A/B=331-634 |
| 8SH1 | X-ray | 2.6 Å | A=1-299 |
| 7S1T | X-ray | 2.9 Å | A/D/G/J=325-634 |
| 8SOJ | EM | 3.8 Å | D=2-634 |
| 7QXB | EM | 3.91 Å | P=1-634 |
| 7QXS | EM | 3.91 Å | P=1-634 |
| 8SOK | EM | 4.1 Å | D=2-634 |
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