Potassium channel subfamily K member 4 (KCNK4) is a 393-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NYG8.
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The mean pLDDT of this model is 78.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, basic pH, heat and lipids (PubMed:22282805, PubMed:25471887, PubMed:25500157, PubMed:26919430, PubMed:30290154, PubMed:38605031). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:26919430). At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1…
Homodimer; disulfide-linked. Forms heterodimers with other 2-pore domain K(+) channel subunits, such as KCNK2 and KCNK10
Cell membrane, Cell projection, axon
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7LJ5 | X-ray | 2.26 Å | A/B=1-264 |
| 4WFE | X-ray | 2.5 Å | A/B=1-264 |
| 4WFF | X-ray | 2.5 Å | A/B=1-264 |
| 4I9W | X-ray | 2.75 Å | A/B=1-274 |
| 7LJA | X-ray | 2.77 Å | A/B=1-264 |
| 7LJ4 | X-ray | 2.78 Å | A/B=1-264 |
| 7LJB | X-ray | 2.97 Å | A/B=1-264 |
| 4WFG | X-ray | 3.0 Å | A/B=1-264 |
| 4WFH | X-ray | 3.01 Å | A/B=1-264 |
| 4RUE | X-ray | 3.3 Å | A/B=1-274 |
| 3UM7 | X-ray | 3.31 Å | A/B=1-274 |
| 4RUF | X-ray | 3.4 Å | A/B=1-274 |
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