Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) is a 906-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9P0K1.
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The mean pLDDT of this model is 73.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1
Interacts with LGI1 (PubMed:27066583). Interacts with DLG4/PSD95 (PubMed:27066583). Also binds LGI4 (By similarity). Interacts with KCNA2 and DLG2 (By similarity). Interacts with ADAM11 (By similarity). Interacts (via C-terminus) with YWHAB/14-3-3 beta (PubMed:15882968). Interacts (via C-terminus) with YWHAZ/14-3-3 zeta (PubMed:12589811)
Cell membrane, Cell projection, axon
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7CQF | X-ray | 1.8 Å | A=892-906 |
| 3G5C | X-ray | 2.36 Å | A/B=233-736 |
| 5Y2Z | X-ray | 2.67 Å | A/C/E/G/I/K=233-729 |
| 9KZC | EM | 2.78 Å | A=233-718 |
| 8HQ2 | X-ray | 2.93 Å | A/B=233-718 |
| 8Y6B | X-ray | 3.49 Å | A/B/C=233-718 |
| 9KZT | EM | 3.79 Å | A/C/E=233-729 |
| 8HQ1 | X-ray | 4.17 Å | A/B/C=233-718 |
| 8HPY | X-ray | 5.87 Å | A/B=233-718 |
| 5Y31 | X-ray | 7.12 Å | A/C=233-729 |
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