Nuclear RNA export factor 1 (NXF1) is a 619-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UBU9.
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The mean pLDDT of this model is 79.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1,…
Heterodimer (via NTF2 domain) with NXT1 (PubMed:11583626). The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export (PubMed:11583626). Forms a complex with RANBP2/NUP358, NXT1 and RANGAP1 (PubMed:14729961). Associates with the exon junction complex (EJC) and with the transcription/export (TREX) complex (PubMed:11707413, PubMed:22893130). Found in a mRNA…
Nucleus, Nucleus, nucleoplasm, Nucleus speckle, Nucleus, nuclear pore complex, Nucleus envelope, Cytoplasm, Cytoplasm, Stress granule
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1OAI | X-ray | 1.0 Å | A=561-619 |
| 9I8A | X-ray | 1.5 Å | B=366-555 |
| 1JKG | X-ray | 1.9 Å | B=371-619 |
| 3RW6 | X-ray | 2.3 Å | A/B=96-362 |
| 2Z5K | X-ray | 2.6 Å | B=53-82 |
| 1JN5 | X-ray | 2.8 Å | B=371-619 |
| 1FO1 | X-ray | 2.9 Å | A/B=102-372 |
| 2Z5M | X-ray | 3.0 Å | B=53-82 |
| 3RW7 | X-ray | 3.0 Å | A/B/C/D=96-362 |
| 1FT8 | X-ray | 3.15 Å | A/B/C/D/E=102-372 |
| 4WYK | X-ray | 3.4 Å | A/C=96-555 |
| 1KOH | X-ray | 3.8 Å | A/B/C/D=96-372 |
| 1KOO | X-ray | 3.8 Å | A/B/C/D=96-372 |
| 6E5U | X-ray | 3.8 Å | A/C/E/G=116-619 |
| 1GO5 | NMR | A=551-619 |
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