Frizzled-4 (FZD4) is a 537-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9ULV1.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 84.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Receptor for Wnt proteins (PubMed:30135577). Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (PubMed:30135577). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (By…
Interacts with MAGI3 and NDP (By similarity). Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP) (By similarity). Interacts (via FZ domain) with TSKU; TSKU competes with WNT2B for binding to FZD4, inhibiting Wnt signaling and repressing peripheral eye development (By similarity). Interacts with glypican GPC3 (PubMed:24496449)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5BPB | X-ray | 2.2 Å | A/B/C/D=42-179 |
| 5BQE | X-ray | 2.3 Å | C=42-179 |
| 5BPQ | X-ray | 2.4 Å | A/B/C/D=42-179 |
| 5CM4 | X-ray | 2.4 Å | A/B=40-164 |
| 6BD4 | X-ray | 2.4 Å | A=178-517 |
| 5UWG | X-ray | 2.56 Å | A/B=40-164 |
| 5BQC | X-ray | 3.0 Å | B=42-179 |
| 6NE1 | X-ray | 3.01 Å | A=42-161 |
| 8WMA | EM | 3.47 Å | A=1-537 |
| 8WM9 | EM | 3.53 Å | A/B=1-537 |
| 5CL1 | X-ray | 3.8 Å | C/D=32-160 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.