5BPQ: Frizzled-4

Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form II. Determined by X-ray diffraction at 2.4 Å resolution. Released 1 Jul 2015.

Method: X-ray diffraction
Resolution: 2.4 Å
Organism: Homo sapiens
Chains: 4
Atoms: 3,835
Mol. weight: 67.74 kDa
Ligands: NAG
Released: 1 Jul 2015

Explore 5BPQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5BPQ contains 32 α-helices and 25 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	45	1
β-strand	46-47	2	1
α-helix	48	1
β-strand	60-61	2	1
α-helix	72-79	8
α-helix	80-82	3
α-helix	83-88	6
α-helix	94-102	9
β-strand	105-107	3	2
β-strand	110-114	5	2
β-strand	116	1	3
α-helix	118-134	17
α-helix	141-143	3
α-helix	145-147	3
β-strand	159	1	3

Chain B: 7 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	46-47	2	4
α-helix	51-53	3
β-strand	60-61	2	4
α-helix	72-80	9
α-helix	83-88	6
α-helix	94-102	9
β-strand	105	1	5
β-strand	110	1	2
β-strand	114	1	5
β-strand	116	1	6
α-helix	118-134	17
α-helix	141-143	3
α-helix	145-147	3
β-strand	159	1	6

Chain C: 7 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	46-47	2	7
β-strand	60-61	2	7
α-helix	72-79	8
α-helix	80-82	3
α-helix	83-88	6
α-helix	94-102	9
β-strand	105	1	8
β-strand	114	1	8
β-strand	116	1	9
α-helix	118-135	18
α-helix	141-143	3
α-helix	145-147	3
β-strand	159	1	9

Chain D: 9 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	46-47	2	10
α-helix	51-53	3
β-strand	60-61	2	10
α-helix	72-79	8
α-helix	80-82	3
α-helix	83-88	6
α-helix	94-102	9
β-strand	105	1	10
α-helix	113	1
β-strand	114	1	10
β-strand	116	1	11
α-helix	118-134	17
α-helix	141-143	3
α-helix	145-147	3
β-strand	159	1	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Frizzled-4	A, B, C, D	protein	149	Homo sapiens	Q9ULV1 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>5BPQ_1 Frizzled-4 (chains A, B, C, D)
DTGERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFL
CSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMC
MEGPGDEEVPLPHKTPIQPGEGTLEVLFQ

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	4

Water and common crystallization additives (CL) are not listed.

Primary citation

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan. Chang, T.H., Hsieh, F.L., Zebisch, M. et al. Elife (2015) 4:e06554. DOI 10.7554/eLife.06554 · PubMed

Other PDB entries of the same protein (UniProt Q9ULV1 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5BPB 2.2 Å, Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form I
5BQE 2.3 Å, Crystal structure of Norrin in complex with the cysteine-rich domain of Frizzled 4…
5CM4 2.4 Å, Crystal structure of human Frizzled 4 Cysteine-Rich Domain (CRD)
6BD4 2.4 Å, Crystal structure of human apo-Frizzled4 receptor
5UWG 2.56 Å, The crystal structure of Fz4-CRD in complex with palmitoleic acid
5BQC 3.0 Å, Crystal structure of Norrin in complex with the cysteine-rich domain of Frizzled 4 and…
6NE1 3.01 Å, Designed repeat protein in complex with Fz4
8WMA 3.47 Å, Fzd4/DEP complex (local refined)
8WM9 3.53 Å, Fzd4/DEP complex
5CL1 3.8 Å, Complex structure of Norrin with human Frizzled 4

Browse structure collections

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