Unconventional myosin-VI (MYO6) is a 1294-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UM54.
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The mean pLDDT of this model is 78.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 54% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized…
Homodimer; dimerization seems to implicate the unfolding of the three-helix bundle region creating an additional calmodulin binding site, and cargo binding (By similarity). Able to function as a monomer under specific conditions in vitro (PubMed:15044955). Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells (PubMed:15247260). Component of the DISP/DOCK7-induced septin…
Golgi apparatus, trans-Golgi network membrane, Golgi apparatus, Nucleus, Cytoplasm, perinuclear region, Membrane, clathrin-coated pit, Cytoplasmic vesicle, clathrin-coated vesicle, Cell projection, filopodium, Cell projection, ruffle membrane, Cell projection, microvillus, Cytoplasm, cytosol,…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6J56 | X-ray | 1.8 Å | A/B=1166-1294 |
| 8W41 | EM | 3.54 Å | A=1-1294 |
| 2N0Z | NMR | A=1080-1122 | |
| 2N10 | NMR | A=1080-1131 | |
| 2N11 | NMR | A=998-1071 | |
| 2N12 | NMR | A=1050-1131 | |
| 2N13 | NMR | A/D=1080-1122 | |
| 6E5N | NMR | B=1050-1131 |
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