2N13: Unconventional myosin-VI

Complex structure of MyUb (1080-1122) of human Myosin VI with K63-diUb. Determined by solution NMR. Released 9 Mar 2016.

Method: Solution NMR
Organism: Homo sapiens
Chains: 4
Atoms: 1,939
Mol. weight: 27.65 kDa
Released: 9 Mar 2016

Explore 2N13 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2N13 contains 11 α-helices and 14 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	20-29	10
α-helix	33-48	16

Chain B: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	102-106	5	1
β-strand	112-116	5	1
β-strand	122	1	2
α-helix	123-133	11
α-helix	138-140	3
β-strand	143-145	3	1
β-strand	148-149	2	1
α-helix	150-151	2
β-strand	155	1	2
α-helix	157-159	3
β-strand	166-169	4	1

Chain C: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	202-206	5	3
β-strand	212-216	5	3
β-strand	222	1	4
α-helix	223-233	11
α-helix	238-240	3
β-strand	242-244	3	3
β-strand	249	1	3
α-helix	250-251	2
β-strand	255	1	4
β-strand	266-270	5	3

Chain D: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	320-329	10
α-helix	333-348	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Unconventional myosin-VI	A, D	protein	43	Homo sapiens	Q9UM54 (AlphaFold model)
Ubiquitin	B	protein	76	Homo sapiens	P0CG47 (AlphaFold model)
Ubiquitin	C	protein	76	Homo sapiens	P0CG47 (AlphaFold model)

Sequence of entity 1 (A, D), FASTA

>2N13_1 Unconventional myosin-VI (chains A, D)
GTKKYDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYH

Sequence of entity 2 (B), FASTA

>2N13_2 Ubiquitin (chains B)
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQRESTLHLVLRLRGG

Sequence of entity 3 (C), FASTA

>2N13_3 Ubiquitin (chains C)
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGC

Primary citation

Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains. He, F., Wollscheid, H.P., Nowicka, U. et al. Cell Rep (2016) 14:2683-2694. DOI 10.1016/j.celrep.2016.01.079 · PubMed

Other PDB entries of the same protein (UniProt Q9UM54 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6J56 1.8 Å, Crystal structure of Myosin VI CBD in complex with Tom1 MBM
8W41 3.54 Å, Cryo-EM structure of Myosin VI in the autoinhibited state
2N0Z Solution structure of MyUb (1080-1122) of human Myosin VI
2N10 Solution structure of MyUb (1080-1131) of human Myosin VI
2N11 Solution structure of human Myosin VI isoform3 (998-1071)
2N12 Solution structure of human Myosin VI isoform3 (1050-1131)
6E5N Solution structure of human Myosin VI isoform 3 (1050-1131) in complex with Clathrin…

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