Transducin-like enhancer protein 6 (Tle6) is a 581-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9WVB3.
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The mean pLDDT of this model is 64.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 40% |
What pLDDT means and how to read it
Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (PubMed:18804437, PubMed:25208553, PubMed:31575650, PubMed:37922900). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:31575650, PubMed:37922900, PubMed:41845018, PubMed:41917274, PubMed:41986725). They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained…
Homodimers (PubMed:16314515). Component of the subcortical maternal complex (SCMC), at least composed of NLRP5, KHDC3, OOEP and TLE6 (PubMed:18804437, PubMed:28992324, PubMed:31575650, PubMed:37922900, PubMed:38177687). Core component of cytoplasmic lattices, at least composed of PADI6, NLRP4F, NLRP5, NLRP14, TLE6, KHDC3, OOEP and ZBED3 (PubMed:31575650, PubMed:41118754, PubMed:41845018,…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8H96 | EM | 2.78 Å | B=1-581 |
| 8H94 | EM | 2.9 Å | B=1-581 |
| 8XI3 | EM | 3.0 Å | B=48-581 |
| 9L4J | EM | 3.0 Å | B=155-581 |
| 8H93 | EM | 3.01 Å | B/E=1-581 |
| 8H95 | EM | 3.38 Å | B=1-581 |
| 9XRL | EM | 3.74 Å | 8/AC/E/I/P/z=155-581 |
| 9SFP | EM | 4.2 Å | W/Y=146-581 |
| 9W2M | EM | 4.2 Å | B/G/b/g=147-581 |
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