Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Magi2) is a 1275-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9WVQ1.
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The mean pLDDT of this model is 64.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 26% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 42% |
What pLDDT means and how to read it
Seems to act as a scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins (By similarity). Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth (By similarity). May play a role in regulating activin-mediated signaling in neuronal cells (PubMed:10681527). Enhances the ability of PTEN to suppress AKT1 activation (By similarity). Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis (PubMed:24608321)
Interacts (via its WW domains) with DRPLA (By similarity). Interacts (via its second PDZ domain) with PTEN (via unphosphorylated C-terminus); this interaction diminishes the degradation rate of PTEN (By similarity). Interacts (via guanylate kinase domain) with DLGAP1 (By similarity). Interacts (via the PDZ domains) with GRIN2A, GRID2 and NLGN1 (By similarity). Interacts with CTNND2, CTNNB1 and…
Cytoplasm, Late endosome, Synapse, synaptosome, Cell membrane, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cell projection, cilium, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, Photoreceptor inner segment, Cell projection, cilium,…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6JJZ | X-ray | 1.65 Å | A/B=295-390 |
| 7YKI | X-ray | 2.0 Å | A/C=9-238 |
| 6KKG | X-ray | 2.15 Å | A/B=295-390 |
| 7YKG | X-ray | 2.16 Å | A/C=9-238 |
| 7YKF | X-ray | 2.28 Å | A/C=9-238 |
| 7YKH | X-ray | 2.5 Å | A/C=9-238 |
| 7D6F | X-ray | 2.7 Å | A=914-1010 |
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