ARF GTPase-activating protein GIT1 (Git1) is a 770-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Z272.
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The mean pLDDT of this model is 73.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 30% |
What pLDDT means and how to read it
GTPase-activating protein for ADP ribosylation factor family members, including ARF1 (PubMed:9826657). Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (PubMed:9826657). Through PAK1 activation, positively regulates microtubule nucleation during interphase. Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (By similarity). May promote cell motility both by regulating focal complex dynamics and by the…
Forms homodimers and possibly oligomers (PubMed:12473661, PubMed:19136011). May form heterooligomers with GIT2 (Probable). Interacts with G protein-coupled receptor kinases, including GRK2, GRK3, GRK5 and GRK6 (PubMed:9826657). Interacts with PPFIA1, PPFIA2 and PPFIA4 (PubMed:12473661, PubMed:12629171). Interacts with GRIP1 and forms a ternary complex with PPFIA1 and GRIP1 (PubMed:12473661,…
Cytoplasm, Synapse, Presynapse, Postsynapse, Postsynaptic density, Cell junction, focal adhesion, Cell projection, lamellipodium, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle pole
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2W6A | X-ray | 1.4 Å | A/B=426-483 |
| 6IUH | X-ray | 1.8 Å | A/B=645-770 |
| 6IUI | X-ray | 2.6 Å | A/B=645-770 |
| 2JX0 | NMR | A=640-770 |
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