1A22: Human growth hormone

Human growth hormone bound to single receptor. Determined by X-ray diffraction at 2.6 Å resolution. Released 29 Apr 1998.

Method: X-ray diffraction
Resolution: 2.6 Å
Organism: Homo sapiens
Chains: 2
Atoms: 3,113
Mol. weight: 49.66 kDa
Released: 29 Apr 1998

Explore 1A22 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1A22 contains 17 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 0 β-strands

Element	Residues	Length
α-helix	7-35	29
α-helix	38-45	8
α-helix	48-51	4
α-helix	54-57	4
α-helix	64-68	5
α-helix	72-85	14
α-helix	89-91	3
α-helix	94-99	6
α-helix	107-128	22
α-helix	137-140	4
α-helix	143-145	3
α-helix	155-184	30

Chain B: 5 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	235-239	5	1
β-strand	240	1	2
β-strand	246-250	5	1
β-strand	265-270	6	3
α-helix	279-280	2
β-strand	281-282	2	3
β-strand	293-296	4	1
β-strand	306-313	8	3
β-strand	316-324	9	3
α-helix	325-327	3
β-strand	329	1	2
α-helix	331-334	4
β-strand	335-341	7	4
β-strand	350-358	9	4
β-strand	372-380	9	5
β-strand	387-388	2	5
β-strand	392	1	5
β-strand	396-403	8	4
β-strand	407-416	10	5
α-helix	424	1
β-strand	425	1	5
α-helix	426-428	3
β-strand	429-432	4	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Growth hormone	A	protein	191	Homo sapiens	P01241 (AlphaFold model)
Growth hormone receptor	B	protein	238	Homo sapiens	P10912 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1A22_1 GROWTH HORMONE (chains A)
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPT
PSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEER
IQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIV
QCRSVEGSCGF

Sequence of entity 2 (B), FASTA

>1A22_2 GROWTH HORMONE RECEPTOR (chains B)
FSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKN
LGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDE
KCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKE
VNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQ

Primary citation

Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity. Clackson, T., Ultsch, M.H., Wells, J.A. et al. J Mol Biol (1998) 277:1111-1128. DOI 10.1006/jmbi.1998.1669 · PubMed

Other PDB entries of the same protein (UniProt P01241 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1HUW 2.0 Å, The crystal structure of affinity-matured human growth hormone at 2 Å resolution
1AXI 2.1 Å, Structural plasticity at the hgh:hghbp interface
1HGU 2.5 Å, Human growth hormone
1HWG 2.5 Å, 1:2 complex of human growth hormone with its soluble binding protein
1KF9 2.6 Å, Phage display derived variant of human growth hormone complexed with two copies of the…
3HHR 2.8 Å, Human growth hormone and extracellular domain of its receptor: crystal structure of the…
1BP3 2.9 Å, The xray structure of a growth hormone-prolactin receptor complex
1HWH 2.9 Å, 1:1 complex of human growth hormone mutant G120R with its soluble binding protein

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