1A36: Topoisomerase i/dna complex

Topoisomerase i/dna complex. Determined by X-ray diffraction at 2.8 Å resolution. Released 12 Aug 1998.

Method
X-ray diffraction
Resolution
2.8 Å
Organism
Homo sapiens
Chains
3
Atoms
5,285
Mol. weight
83.52 kDa
Released
12 Aug 1998

Explore 1A36 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1A36 contains 32 α-helices and 21 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 32 helices, 21 β-strands

ElementResiduesLengthSheet
β-strand220-22231
α-helix2251
β-strand22612
α-helix227-2315
α-helix233-2353
β-strand240-24233
β-strand245-24733
α-helix251-26111
α-helix267-2704
α-helix272-28413
α-helix288-2936
α-helix297-2993
β-strand300-30123
α-helix303-31816
α-helix321-33818
β-strand340-34341
β-strand346-34941
β-strand35014
β-strand35412
β-strand359-36025
α-helix3721
β-strand373-37425
α-helix375-3773
α-helix379-3813
β-strand383-38536
α-helix392-3965
β-strand403-40536
β-strand414-41746
β-strand424-42746
β-strand42914
α-helix434-46431
α-helix470-48415
α-helix491-4944
α-helix504-5063
β-strand50817
α-helix509-5113
β-strand512-51878
β-strand521-530108
α-helix532-5343
β-strand536-54278
α-helix545-55511
β-strand56317
α-helix570-58011
α-helix586-60520
α-helix612-62918
α-helix643-67432
α-helix679-71032
α-helix717-7182
α-helix719-7235
α-helix726-73510
α-helix740-7423
α-helix746-7516
α-helix753-7575

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
DNA (5'-d(*ap*ap*ap*ap*ap*gp*ap*cp*tp*tp*ap*gp*ap*ap*ap*ap*a p*tp*tp*tp*tp*t)- 3')BDNA22
DNA (5'-d(*ap*ap*ap*ap*ap*tp*tp*tp*tp*tp*cp*tp*ap*ap*gp*tp*c p*tp*tp*tp*tp*t)- 3')CDNA22
Topoisomerase IAprotein591Homo sapiensP11387 (AlphaFold model)
Sequence of entity 1 (B), FASTA
>1A36_1 DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*A P*TP*TP*TP*TP*T)- 3') (chains B)
AAAAAGACTTAGAAAAATTTTT
Sequence of entity 2 (C), FASTA
>1A36_2 DNA (5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*C P*TP*TP*TP*TP*T)- 3') (chains C)
AAAAATTTTTCTAAGTCTTTTT
Sequence of entity 3 (A), FASTA
>1A36_3 TOPOISOMERASE I (chains A)
KPKNKDKDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPL
PENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNII
TNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFK
IEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLV
SWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQ
RAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDS
IRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNA
SITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAK
KEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQI
ALGTSKLNFLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF

Primary citation

A model for the mechanism of human topoisomerase I. Stewart, L., Redinbo, M.R., Qiu, X. et al. Science (1998) 279:1534-1541. DOI 10.1126/science.279.5356.1534 · PubMed

Other PDB entries of the same protein (UniProt P11387 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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1A36 is part of these collections:

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