Complex porcine pancreatic trypsin/soybean trypsin inhibitor, tetragonal crystal form. Determined by X-ray diffraction at 1.9 Å resolution. Released 28 Oct 1998.
Explore 1AVX in 3D Show helices and sheets RCSB PDB PDBe
1AVX contains 13 α-helices and 40 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 17 | 1 | 1 |
| β-strand | 20-21 | 2 | 2 |
| α-helix | 22-23 | 2 | |
| β-strand | 30-34 | 5 | 3 |
| β-strand | 40-48 | 9 | 3 |
| β-strand | 51-54 | 4 | 3 |
| α-helix | 56-58 | 3 | |
| β-strand | 64-67 | 4 | 3 |
| β-strand | 72 | 1 | 4 |
| β-strand | 81-90 | 10 | 3 |
| β-strand | 104-108 | 5 | 3 |
| α-helix | 121-124 | 4 | |
| α-helix | 128-130 | 3 | |
| β-strand | 135-140 | 6 | 2 |
| β-strand | 154 | 1 | 4 |
| β-strand | 156-163 | 8 | 2 |
| α-helix | 165-171 | 7 | |
| β-strand | 180-183 | 4 | 2 |
| β-strand | 189 | 1 | 1 |
| β-strand | 198-201 | 4 | 2 |
| β-strand | 204-215 | 8 | 2 |
| β-strand | 226-229 | 4 | 2 |
| α-helix | 231-234 | 4 | |
| α-helix | 235-244 | 10 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 502 | 1 | 5 |
| α-helix | 503 | 1 | |
| β-strand | 504 | 1 | 6 |
| α-helix | 505 | 1 | |
| α-helix | 509 | 1 | |
| β-strand | 510 | 1 | 6 |
| α-helix | 511 | 1 | |
| β-strand | 512 | 1 | 7 |
| β-strand | 516-521 | 6 | 8 |
| β-strand | 529-532 | 4 | 9 |
| β-strand | 542-545 | 4 | 9 |
| β-strand | 555-557 | 3 | 8 |
| β-strand | 562 | 1 | 2 |
| β-strand | 566 | 1 | 7 |
| α-helix | 567 | 1 | |
| β-strand | 568 | 1 | 5 |
| β-strand | 573 | 1 | 8 |
| β-strand | 576-577 | 2 | 8 |
| α-helix | 578-579 | 2 | |
| β-strand | 592 | 1 | 8 |
| β-strand | 594-596 | 3 | 9 |
| β-strand | 604-606 | 3 | 9 |
| β-strand | 613 | 1 | 9 |
| β-strand | 616-622 | 7 | 8 |
| β-strand | 631-637 | 7 | 8 |
| β-strand | 646-647 | 2 | 8 |
| β-strand | 649-652 | 4 | 9 |
| β-strand | 659-662 | 4 | 9 |
| β-strand | 670-675 | 6 | 8 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Trypsin | A | protein | 223 | Sus scrofa | P00761 (AlphaFold model) |
| Trypsin inhibitor | B | protein | 177 | Glycine max | P01070 (AlphaFold model) |
>1AVX_1 TRYPSIN (chains A) IVGGYTCAANSIPYQVSLNSGSHFCGGSLINSQWVVSAAHCYKSRIQVRLGEHNIDVLEG NEQFINAAKIITHPNFNGNTLDNDIMLIKLSSPATLNSRVATVSLPRSCAAAGTECLISG WGNTKSSGSSYPSLLQCLKAPVLSDSSCKSSYPGQITGNMICVGFLEGGKDSCQGDSGGP VVCNGQLQGIVSWGYGCAQKNKPGVYTKVCNYVNWIQQTIAAN
>1AVX_2 TRYPSIN INHIBITOR (chains B) DFVLDNEGNPLENGGTYYILSDITAFGGIRAAPTGNERCPLTVVQSRNELDKGIGTIISS PYRIRFIAEGHPLSLKFDSFAVIMLCVGIPTEWSVVEDLPEGPAVKIGENKDAMDGWFRL ERVSDDEFNNYKLVFCPQQAEDDKCGDIGISIDHDDGTRRLVVSKNKPLVVQFQKLD
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 1 |
Kunitz-type soybean trypsin inhibitor revisited: refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator. Song, H.K., Suh, S.W. J Mol Biol (1998) 275:347-363. DOI 10.1006/jmbi.1997.1469 · PubMed
Other PDB entries of the same protein (UniProt P00761 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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