1AXI: Structural plasticity at the hgh:hghbp interface

Structural plasticity at the hgh:hghbp interface. Determined by X-ray diffraction at 2.1 Å resolution. Released 28 Jan 1998.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: Homo sapiens
Chains: 2
Atoms: 3,321
Mol. weight: 49.35 kDa
Released: 28 Jan 1998

Explore 1AXI in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1AXI contains 15 α-helices and 17 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 0 β-strands

Element	Residues	Length
α-helix	7-35	29
α-helix	38-46	9
α-helix	54-57	4
α-helix	64-68	5
α-helix	72-86	15
α-helix	89-93	5
α-helix	94-99	6
α-helix	107-127	21
α-helix	137-140	4
α-helix	156-184	29

Chain B: 5 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	35-39	5	1
β-strand	40	1	2
β-strand	46-50	5	1
β-strand	65-70	6	3
β-strand	81-82	2	3
β-strand	93-96	4	1
α-helix	98-100	3
β-strand	106-113	8	3
β-strand	116-124	9	3
α-helix	125-128	4
β-strand	129	1	2
α-helix	131-134	4
β-strand	135-141	7	4
β-strand	150-158	9	4
β-strand	172-180	9	5
α-helix	186	1
β-strand	187-188	2	5
α-helix	189-191	3
β-strand	192	1	5
β-strand	196-203	8	4
β-strand	208-216	9	5
β-strand	229-231	3	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Growth hormone	A	protein	191	Homo sapiens	P01241 (AlphaFold model)
Growth hormone receptor	B	protein	236	Homo sapiens	P10912 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1AXI_1 GROWTH HORMONE (chains A)
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPT
PSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEER
IQTLMGRLTDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRRDMTYVATYLRIV
QCRSVEGSCGF

Sequence of entity 2 (B), FASTA

>1AXI_2 GROWTH HORMONE RECEPTOR (chains B)
FSGSEATAAILSRAPWSLQSVNPGLKTNSSGEPKFTKCRSPERETFSCHWTDEVHHGTKN
EGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIAIPYCIKLTSNGGTVDE
KCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKE
VNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQM

Primary citation

Structural plasticity in a remodeled protein-protein interface. Atwell, S., Ultsch, M., De Vos, A.M. et al. Science (1997) 278:1125-1128. DOI 10.1126/science.278.5340.1125 · PubMed

Other PDB entries of the same protein (UniProt P01241 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1HUW 2.0 Å, The crystal structure of affinity-matured human growth hormone at 2 Å resolution
1HGU 2.5 Å, Human growth hormone
1HWG 2.5 Å, 1:2 complex of human growth hormone with its soluble binding protein
1A22 2.6 Å, Human growth hormone bound to single receptor
1KF9 2.6 Å, Phage display derived variant of human growth hormone complexed with two copies of the…
3HHR 2.8 Å, Human growth hormone and extracellular domain of its receptor: crystal structure of the…
1BP3 2.9 Å, The xray structure of a growth hormone-prolactin receptor complex
1HWH 2.9 Å, 1:1 complex of human growth hormone mutant G120R with its soluble binding protein

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