1CKK: Calmodulin-1

Calmodulin/rat CA2+/CALMODULIN dependent protein kinase fragment. Determined by solution NMR. Released 10 Sept 1999.

Method: Solution NMR
Organisms: Xenopus laevis, Rattus norvegicus
Chains: 2
Atoms: 1,383
Mol. weight: 19.91 kDa
Ligands: CA
Released: 10 Sept 1999

Explore 1CKK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1CKK contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	5-19	15
β-strand	27	1	1
α-helix	29-38	10
α-helix	45-55	11
β-strand	63	1	1
α-helix	65-71	7
α-helix	83-92	10
β-strand	100	1	2
α-helix	102-112	11
α-helix	119-128	10
β-strand	136	1	2
α-helix	138-146	9

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	7-16	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin-1	A	protein	148	Xenopus laevis	P0DP33 (AlphaFold model)
Calcium/calmodulin-dependent protein kinase kinase 1	B	protein	26	Rattus norvegicus	P97756 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1CKK_1 Calmodulin-1 (chains A)
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B), FASTA

>1CKK_2 Calcium/calmodulin-dependent protein kinase kinase 1 (chains B)
VKLIPSWTTVILVKSMLRKRSFGNPF

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

A novel target recognition revealed by calmodulin in complex with Ca2+-calmodulin-dependent kinase kinase. Osawa, M., Tokumitsu, H., Swindells, M.B. et al. Nat Struct Biol (1999) 6:819-824. DOI 10.1038/12271 · PubMed

Other PDB entries of the same protein (UniProt P0DP33 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1IQ5 1.8 Å, Calmodulin/nematode CA2+/Calmodulin dependent kinase kinase fragment
2COL 2.2 Å, Crystal structure analysis of CyaA/C-Cam with Pyrophosphate
4R8G 3.5 Å, Crystal Structure of Myosin-1c tail in complex with Calmodulin
1Y0V 3.6 Å, Crystal structure of anthrax edema factor (EF) in complex with calmodulin and…
1CFC Calcium-free calmodulin
1CFD Calcium-free calmodulin
1CFF NMR solution structure of a complex of calmodulin with a binding peptide of the CA2+-pump
1DMO Calmodulin, NMR, 30 structures
1F70 Refined solution structure of calmodulin N-terminal domain
1F71 Refined solution structure of calmodulin C-terminal domain
1MUX Solution NMR structure of calmodulin/w-7 complex: the basis of diversity in molecular…
1NWD Solution Structure of Ca2+/Calmodulin bound to the C-terminal Domain of Petunia…

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