1DKT: Cyclin dependent kinase subunit, type 1

CKSHS1: human cyclin dependent kinase subunit, type 1 complex with metavanadate. Determined by X-ray diffraction at 2.9 Å resolution. Released 8 Mar 1996.

Method: X-ray diffraction
Resolution: 2.9 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,325
Mol. weight: 20.02 kDa
Ligands: V7O
Released: 8 Mar 1996

Explore 1DKT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1DKT contains 5 α-helices and 10 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	7-9	3	1
β-strand	12-13	2	1
β-strand	17-23	7	1
α-helix	26-31	6
α-helix	40-46	7
β-strand	55-58	4	1
β-strand	66-72	7	1

Chain B: 3 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	7-9	3	1
β-strand	12-13	2	1
β-strand	17-23	7	1
α-helix	28-31	4
α-helix	37-39	3
α-helix	40-46	7
β-strand	55-58	4	1
β-strand	66-72	7	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Cyclin dependent kinase subunit, type 1	A, B	protein	79	Homo sapiens	P61024 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>1DKT_1 CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 (chains A, B)
MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIH
EPEPHILLFRRPLPKKPKK

Ligands and cofactors

ID	Name	Formula	Copies
V7O	Meta vanadate	O19 V7	1

Primary citation

Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. Arvai, A.S., Bourne, Y., Hickey, M.J. et al. J Mol Biol (1995) 249:835-842. DOI 10.1006/jmbi.1995.0341 · PubMed

Other PDB entries of the same protein (UniProt P61024 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2AST 2.3 Å, Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide
1BUH 2.6 Å, Crystal structure of the human CDK2 kinase complex with cell cycle-regulatory protein…
4YC6 2.6 Å, CDK1/CKS1
9QO4 2.95 Å, Dissociation-state-3 of 9-subunit CSN and SCF (SKP1-SKP2-CKS1) complex
2ASS 3.0 Å, Crystal structure of the Skp1-Skp2-Cks1 complex
8OR0 3.1 Å, CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2
1DKS 3.2 Å, CKSHS1: human cyclin dependent kinase subunit, type 1 in complex with phosphate
9QO0 3.26 Å, Pre-activated 9-subunit COP9 signalosome and neddylated SCF (Skp1-Skp2-Cks1) complex…
8BYA 3.38 Å, Cryo-EM structure of SKP1-SKP2-CKS1-CDK2-CyclinA-p27KIP1 Complex
8BYL 3.5 Å, Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex
7NJ0 3.6 Å, CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex
7B5L 3.8 Å, Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly:…

Browse structure collections

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