1F86: Transthyretin THR119MET protein stabilisation

Transthyretin THR119MET protein stabilisation. Determined by X-ray diffraction at 1.1 Å resolution. Released 29 Jun 2001.

Method: X-ray diffraction
Resolution: 1.1 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,182
Mol. weight: 26.83 kDa
Ligands: T44
Released: 29 Jun 2001

Explore 1F86 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1F86 contains 2 α-helices and 22 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 12 β-strands

Element	Residues	Length	Sheet
β-strand	12-18	7	1
β-strand	23-24	2	1
β-strand	29-35	7	2
β-strand	41-48	8	2
β-strand	54-55	2	1
β-strand	67-73	7	2
α-helix	75-81	7
β-strand	88-90	3	3
β-strand	91-97	7	2
β-strand	99	1	4
β-strand	101	1	4
β-strand	104-112	9	1
β-strand	115-123	9	1

Chain B: 1 helix, 10 β-strands

Element	Residues	Length	Sheet
β-strand	12-18	7	1
β-strand	23-24	2	1
β-strand	29-35	7	3
β-strand	41-48	8	3
β-strand	54-55	2	1
β-strand	67-73	7	3
α-helix	75-81	7
β-strand	88-90	3	2
β-strand	91-97	7	3
β-strand	104-111	8	1
β-strand	115-123	9	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Transthyretin THR119MET variant	A, B	protein	115	Homo sapiens	P02766 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>1F86_1 TRANSTHYRETIN THR119MET VARIANT (chains A, B)
CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIY
KVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTMAVVTN

Ligands and cofactors

ID	Name	Formula	Copies
T44	3,5,3',5'-tetraiodo-L-thyronine	C15 H11 I4 N O4	2

Primary citation

Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution. Sebastiao, M.P., Lamzin, V., Saraiva, M.J. et al. J Mol Biol (2001) 306:733-744. DOI 10.1006/jmbi.2000.4415 · PubMed

Other PDB entries of the same protein (UniProt P02766 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8C86 1.1 Å, Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 2
8W45 1.1 Å, X-ray crystal structure of V30M-TTR in complex with pinostilbene
4QXV 1.12 Å, Crystal structure of human transthyretin in complex with luteolin at 1.1 a resolution
4KY2 1.13 Å, Transthyretin in complex with the fluorescent folding sensor…
4D7B 1.15 Å, Structure of human transthyretin in complex with Tolcapone
7EJQ 1.15 Å, Crystal structure of human transthyretin in complex with…
8AWI 1.15 Å, Crystal structure of Human Transthyretin at 1.15 Angstrom resolution
6TXW 1.15 Å, V30G Transthyretin structure in complex with Tolcalpone
4L1T 1.16 Å, Transthyretin in complex with (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzo…
4HIQ 1.18 Å, The Structure of V122I Mutant Transthyretin in Complex with AG10
9H7L 1.18 Å, Human Transthyretin in Complex with 4-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine
8C85 1.19 Å, Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 1

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