Transthyretin (TTR) is a 147-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02766.
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The mean pLDDT of this model is 88.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 78% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain
Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4
Secreted, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1F86 | X-ray | 1.1 Å | A/B=30-144 |
| 8C86 | X-ray | 1.1 Å | A/B=21-147 |
| 8W45 | X-ray | 1.1 Å | A/B=1-147 |
| 4QXV | X-ray | 1.12 Å | A/B=21-147 |
| 4KY2 | X-ray | 1.13 Å | A/B=21-147 |
| 4D7B | X-ray | 1.15 Å | A/B=21-147 |
| 6TXW | X-ray | 1.15 Å | A/B=30-145 |
| 7EJQ | X-ray | 1.15 Å | A/B=1-146 |
| 8AWI | X-ray | 1.15 Å | A/B=29-147 |
| 4L1T | X-ray | 1.16 Å | A/B=21-147 |
| 4HIQ | X-ray | 1.18 Å | A/B=21-147 |
| 9H7L | X-ray | 1.18 Å | A/B=21-147 |
| 8C85 | X-ray | 1.19 Å | A/B=21-147 |
| 8W48 | Other | 1.19 Å | A/B=1-147 |
| 3M1O | X-ray | 1.2 Å | A/B=21-147 |
| 4HIS | X-ray | 1.2 Å | A/B=21-147 |
| 5DWP | X-ray | 1.2 Å | A/B=30-145 |
| 5FW7 | X-ray | 1.2 Å | A/B=21-147 |
| 5JID | X-ray | 1.2 Å | A/B=21-147 |
| 7DT3 | X-ray | 1.2 Å | A/B=1-147 |
Showing 20 of 459 experimental structures (best resolution first).
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