Crystal structure of human neutrophil elastase complexed with an inhibitor (GW475151). Determined by X-ray diffraction at 2.0 Å resolution. Released 29 Aug 2002.
Explore 1H1B in 3D Show helices and sheets RCSB PDB PDBe
1H1B contains 12 α-helices and 40 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 17 | 1 | 1 |
| β-strand | 20-21 | 2 | 2 |
| α-helix | 22-23 | 2 | |
| β-strand | 30-35 | 6 | 3 |
| β-strand | 39-48 | 10 | 3 |
| β-strand | 51-54 | 4 | 3 |
| α-helix | 56-60 | 5 | |
| α-helix | 62B-64 | 3 | |
| β-strand | 65-68 | 5 | 3 |
| β-strand | 72 | 1 | 4 |
| β-strand | 81-83 | 3 | 3 |
| β-strand | 85-94 | 9 | 3 |
| β-strand | 104-108 | 5 | 3 |
| β-strand | 135-140 | 6 | 2 |
| β-strand | 143 | 1 | 5 |
| β-strand | 151 | 1 | 5 |
| β-strand | 154 | 1 | 4 |
| β-strand | 156-163 | 7 | 2 |
| β-strand | 181-184 | 4 | 2 |
| β-strand | 189 | 1 | 1 |
| β-strand | 198-201 | 4 | 2 |
| β-strand | 208-215 | 8 | 2 |
| β-strand | 226-230 | 5 | 2 |
| α-helix | 231-234 | 4 | |
| α-helix | 235-242 | 8 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 17 | 1 | 6 |
| β-strand | 20-21 | 2 | 7 |
| α-helix | 22-23 | 2 | |
| β-strand | 30-35 | 6 | 3 |
| β-strand | 39-48 | 10 | 3 |
| β-strand | 51-54 | 4 | 3 |
| α-helix | 56-59 | 4 | |
| α-helix | 62B-64 | 3 | |
| β-strand | 65A-68 | 4 | 3 |
| β-strand | 72 | 1 | 8 |
| β-strand | 81-94 | 13 | 3 |
| β-strand | 104-108 | 5 | 3 |
| β-strand | 122 | 1 | 7 |
| α-helix | 124-125 | 2 | |
| α-helix | 129-131 | 3 | |
| β-strand | 135-140 | 6 | 7 |
| β-strand | 147 | 1 | 9 |
| β-strand | 149 | 1 | 9 |
| β-strand | 154 | 1 | 8 |
| β-strand | 156-164 | 8 | 7 |
| β-strand | 181-184 | 4 | 7 |
| β-strand | 189 | 1 | 6 |
| β-strand | 198-201 | 4 | 7 |
| β-strand | 208-215 | 8 | 7 |
| β-strand | 226-230 | 5 | 7 |
| α-helix | 231-233 | 3 | |
| α-helix | 235-242 | 8 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Leukocyte elastase | A, B | protein | 218 | HOMO SAPIENS | P08246 (AlphaFold model) |
>1H1B_1 LEUKOCYTE ELASTASE (chains A, B) IVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNL SRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGV QCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCN GLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQ
| ID | Name | Formula | Copies |
|---|---|---|---|
| 151 | (2S)-3-methyl-2-((2R,3S)-3-[(methylsulfonyl)amino]-1-{[2-(pyrrolidin-1-ylmethyl… | C19 H30 N4 O6 S | 2 |
Discovery of Further Pyrrolidine Trans-Lactams as Inhibitors of Human Neutrophil Elastase (Hne) with Potential as Development Candidates and the Crystal Structure of Hne Complexed with an Inhibitor (Gw475151). Macdonald, S.J.F., Dowle, M.D., Harrison, L.A. et al. J Med Chem (2002) 45:3878. DOI 10.1021/JM020881F · PubMed
Other PDB entries of the same protein (UniProt P08246 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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