1HTH: Cyclic parathyroid hormone

Name: PDB 1HTH: The solution structure of cyclic human parathyroid hormone fragment 1-34, NMR, 10 structures
Published: 1997-10-15
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: hormone

The solution structure of cyclic human parathyroid hormone fragment 1-34, NMR, 10 structures. Determined by solution NMR. Released 15 Oct 1997.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 290
Mol. weight: 4.12 kDa
Released: 15 Oct 1997

Explore 1HTH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1HTH contains 4 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	4-6	3
α-helix	8-11	4
α-helix	20-26	7
α-helix	27-31	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Cyclic parathyroid hormone	A	protein	34	Homo sapiens	P01270 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1HTH_1 CYCLIC PARATHYROID HORMONE (chains A)
SVSEIQLLHNLGAHLNELERVEWLRKKLQDVHNF

Primary citation

The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution. Weidler, M., Marx, U.C., Seidel, G. et al. FEBS Lett (1999) 444:239-244. DOI 10.1016/S0014-5793(98)01658-5 · PubMed

Other PDB entries of the same protein (UniProt P01270 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1ET1 0.9 Å, Crystal structure of human parathyroid hormone 1-34 at 0.9 a resolution
3C4M 1.95 Å, Structure of human parathyroid hormone in complex with the extracellular domain of its…
8T5F 1.99 Å, De novo design of high-affinity protein binders to bioactive helical peptides
8FLQ 2.55 Å, Human PTH1R in complex with PTH(1-34) and Gs
8HA0 2.62 Å, Molecular recognition of two endogenous hormones by the human parathyroid hormone…
7VVL 2.8 Å, PTH-bound human PTH1R in complex with Gs (class2)
7Y36 2.8 Å, Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex
9JR2 2.8 Å, Cryo-EM structure of PTH-PTH1R-Gq (upright state)
9JR3 2.8 Å, Cryo-EM structure of PTH-PTH1R-Gq (tilted state)
7VVM 3.2 Å, PTH-bound human PTH1R in complex with Gs (class3)
7VVK 3.3 Å, PTH-bound human PTH1R in complex with Gs (class1)
8HAO 3.76 Å, Human parathyroid hormone receptor-1 dimer

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