1IC2: Tropomyosin alpha chain, skeletal muscle

Deciphering the design of the tropomyosin molecule. Determined by X-ray diffraction at 2.0 Å resolution. Released 25 Jul 2001.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Gallus gallus
Chains: 4
Atoms: 2,670
Mol. weight: 37.09 kDa
Released: 25 Jul 2001

Explore 1IC2 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1IC2 contains 5 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3-74	72
α-helix	75-77	3

Chains B and C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3-75	73

Chain D: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3-73	71

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Tropomyosin alpha chain, skeletal muscle	A, B, C, D	protein	81	Gallus gallus	P04268 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>1IC2_1 TROPOMYOSIN ALPHA CHAIN, SKELETAL MUSCLE (chains A, B, C, D)
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEERSKQLEDELVALQKKLKGTEDELDKY
SESLKDAQEKLELADKKATDC

Primary citation

Deciphering the design of the tropomyosin molecule. Brown, J.H., Kim, K.-H., Jun, G. et al. Proc Natl Acad Sci U S A (2001) 98:8496-8501. DOI 10.1073/pnas.131219198 · PubMed

Other PDB entries of the same protein (UniProt P04268 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3U1C 1.8 Å, Anti-parallel dimer of N-terminal 98-aa fragment of smooth muscle tropomyosin alpha
3U1A 2.0 Å, N-terminal 81-aa fragment of smooth muscle tropomyosin alpha
3MTU 2.1 Å, Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle
3MUD 2.2 Å, Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle

Browse structure collections

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