1MGS: Melanoma growth stimulating activity

The solution structure of melanoma growth stimulating activity. Determined by solution NMR. Released 30 Sept 1994.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 1,094
Mol. weight: 15.75 kDa
Released: 30 Sept 1994

Explore 1MGS in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1MGS contains 2 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 1 helix, 4 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	1
β-strand	23-29	7	1
β-strand	39-44	6	1
β-strand	49-52	4	1
α-helix	57-69	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Human melanoma growth stimulatory activity	A, B	protein	73	Homo sapiens	P09341 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>1MGS_1 HUMAN MELANOMA GROWTH STIMULATORY ACTIVITY (chains A, B)
ASVATELRCQCLQTLQGIHPKNIQSVNVKSPGPHCAQTEVIATLKNGRKACLNPASPIVK
KIIEKMLNSDKSN

Primary citation

The solution structure of melanoma growth stimulating activity. Fairbrother, W.J., Reilly, D., Colby, T.J. et al. J Mol Biol (1994) 242:252-270. DOI 10.1006/jmbi.1994.1577 · PubMed

Other PDB entries of the same protein (UniProt P09341 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9EJC 2.98 Å, Cryo-EM Structure of CXCL1-KSHV ORF74-Gi-scFv16 Complex
8K4O 3.01 Å, Cryo-EM structure of Kaposi's Sarcoma-Associated Herpesvirus-G Protein-Coupled Receptor…
8XWV 3.07 Å, Structure of CXCR2 bound to CXCL1 (CXCR2-CXCL1-Go Full map)
8XWA 3.48 Å, Structure of CXCR2 bound to CXCL1 (Ligand-receptor focused map)
1MSG Solution structure of gro(slash)melanoma growth stimulatory activity determined by 1H…
1MSH Solution structure of gro(slash)melanoma growth stimulatory activity determined by 1H…
1ROD Chimeric protein of interleukin 8 and human melanoma growth stimulating activity…

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