1N6U: Interferon-alpha/beta receptor beta chain

NMR structure of the interferon-binding ectodomain of the human interferon receptor. Determined by solution NMR. Released 15 Jul 2003.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 1,710
Mol. weight: 24.32 kDa
Released: 15 Jul 2003

Explore 1N6U in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1N6U contains 5 α-helices and 21 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	13	1	1
α-helix	14-15	2
β-strand	16-19	4	2
β-strand	22-25	4	2
β-strand	28	1	1
β-strand	39-45	7	3
β-strand	48-54	7	3
α-helix	56-58	3
β-strand	61	1	3
α-helix	65	1
β-strand	66-68	3	2
β-strand	78-85	8	3
β-strand	86-87	2	4
β-strand	90-91	2	4
β-strand	95-100	6	3
α-helix	101-104	4
β-strand	107	1	2
β-strand	111-116	6	5
β-strand	121-126	6	5
α-helix	132-134	3
β-strand	140-147	8	6
β-strand	150	1	6
β-strand	153	1	6
β-strand	165-168	4	5
β-strand	179-186	8	6
β-strand	200-201	2	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interferon-alpha/beta receptor beta chain	A	protein	212	Homo sapiens	P48551 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1N6U_1 Interferon-alpha/beta receptor beta chain (chains A)
SYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCAN
TTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNH
INVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYC
VSVYLEHSDEQAVIKSPLKCTLLPPGQESEFS

Primary citation

The human type I interferon receptor. NMR structure reveals the molecular basis of ligand binding. Chill, J.H., Quadt, S.R., Levy, R. et al. Structure (2003) 11:791-802. DOI 10.1016/S0969-2126(03)00120-5 · PubMed

Other PDB entries of the same protein (UniProt P48551 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3S9D 2.0 Å, binary complex between IFNa2 and IFNAR2
3S8W 2.6 Å, D2 domain of human IFNAR2
3SE4 3.5 Å, human IFNw-IFNAR ternary complex
3SE3 4.0 Å, human IFNa2-IFNAR ternary complex
1N6V Average structure of the interferon-binding ectodomain of the human type I interferon…
2HYM NMR based Docking Model of the Complex between the Human Type I Interferon Receptor and…
2KZ1 Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by…
2LAG Structure of the 44 kDa complex of interferon-alpha2 with the extracellular part of…

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