1NWD: Ca2+/Calmodulin

Solution Structure of Ca2+/Calmodulin bound to the C-terminal Domain of Petunia Glutamate Decarboxylase. Determined by solution NMR. Released 8 Apr 2003.

Method: Solution NMR
Organisms: Xenopus laevis, Petunia x hybrida
Chains: 3
Atoms: 1,638
Mol. weight: 23.57 kDa
Ligands: CA
Released: 8 Apr 2003

Explore 1NWD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1NWD contains 11 α-helices and 2 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	7-19	13
β-strand	26-27	2	1
α-helix	29-39	11
α-helix	45-53	9
β-strand	63-64	2	1
α-helix	65-69	5
α-helix	70-74	5
α-helix	82-92	11
α-helix	102-113	12
α-helix	119-123	5
α-helix	138-145	8

Chains B and C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	7-25	19

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A	protein	148	Xenopus laevis	P0DP33 (AlphaFold model)
Glutamate decarboxylase	B, C	protein	28	Petunia x hybrida	Q07346 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1NWD_1 Calmodulin (chains A)
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B, C), FASTA

>1NWD_2 Glutamate decarboxylase (chains B, C)
GSHKKTDSEVQLEMITAWKKFVEEKKKK

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

Structural Basis for Simultaneous Binding of Two Carboxy-terminal Peptides of Plant Glutamate Decarboxylase to Calmodulin. Yap, K.L., Yuan, T., Mal, T.K. et al. J Mol Biol (2003) 328:193-204. DOI 10.1016/S0022-2836(03)00271-7 · PubMed

Other PDB entries of the same protein (UniProt P0DP33 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1IQ5 1.8 Å, Calmodulin/nematode CA2+/Calmodulin dependent kinase kinase fragment
2COL 2.2 Å, Crystal structure analysis of CyaA/C-Cam with Pyrophosphate
4R8G 3.5 Å, Crystal Structure of Myosin-1c tail in complex with Calmodulin
1Y0V 3.6 Å, Crystal structure of anthrax edema factor (EF) in complex with calmodulin and…
1CFC Calcium-free calmodulin
1CFD Calcium-free calmodulin
1CFF NMR solution structure of a complex of calmodulin with a binding peptide of the CA2+-pump
1CKK Calmodulin/rat CA2+/CALMODULIN dependent protein kinase fragment
1DMO Calmodulin, NMR, 30 structures
1F70 Refined solution structure of calmodulin N-terminal domain
1F71 Refined solution structure of calmodulin C-terminal domain
1MUX Solution NMR structure of calmodulin/w-7 complex: the basis of diversity in molecular…

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